TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival

TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival

Interleukin-15 (IL-15) regulates the homeostasis of many immune cell types, including natural killer T (NKT) cells, but the underlying mechanism is not completely clear. Here the authors analyse Tbkbp1-deficient mice and show that IL-15 induces Tbkbp1-dependent autophagy to modulate NKT survival.

Bibliographic Details
Main Authors: Lele Zhu, Xiaoping Xie, Lingyun Zhang, Hui Wang, Zuliang Jie, Xiaofei Zhou, Jianhong Shi, Shuli Zhao, Boxiang Zhang, Xuhong Cheng, Shao-Cong Sun
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05097-5
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spelling doaj-92aecf591e844ff9a8cf1378b35aec462021-05-11T09:21:52ZengNature Publishing GroupNature Communications2041-17232018-07-019111410.1038/s41467-018-05097-5TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survivalLele Zhu0Xiaoping Xie1Lingyun Zhang2Hui Wang3Zuliang Jie4Xiaofei Zhou5Jianhong Shi6Shuli Zhao7Boxiang Zhang8Xuhong Cheng9Shao-Cong Sun10Department of Immunology, The University of Texas MD Anderson Cancer CenterDepartment of Immunology, The University of Texas MD Anderson Cancer CenterDepartment of Immunology, The University of Texas MD Anderson Cancer CenterDepartment of Immunology, The University of Texas MD Anderson Cancer CenterDepartment of Immunology, The University of Texas MD Anderson Cancer CenterDepartment of Immunology, The University of Texas MD Anderson Cancer CenterDepartment of Immunology, The University of Texas MD Anderson Cancer CenterDepartment of Immunology, The University of Texas MD Anderson Cancer CenterDepartment of Immunology, The University of Texas MD Anderson Cancer CenterDepartment of Immunology, The University of Texas MD Anderson Cancer CenterDepartment of Immunology, The University of Texas MD Anderson Cancer CenterInterleukin-15 (IL-15) regulates the homeostasis of many immune cell types, including natural killer T (NKT) cells, but the underlying mechanism is not completely clear. Here the authors analyse Tbkbp1-deficient mice and show that IL-15 induces Tbkbp1-dependent autophagy to modulate NKT survival.https://doi.org/10.1038/s41467-018-05097-5
collection DOAJ
language English
format Article
sources DOAJ
author Lele Zhu
Xiaoping Xie
Lingyun Zhang
Hui Wang
Zuliang Jie
Xiaofei Zhou
Jianhong Shi
Shuli Zhao
Boxiang Zhang
Xuhong Cheng
Shao-Cong Sun
spellingShingle Lele Zhu
Xiaoping Xie
Lingyun Zhang
Hui Wang
Zuliang Jie
Xiaofei Zhou
Jianhong Shi
Shuli Zhao
Boxiang Zhang
Xuhong Cheng
Shao-Cong Sun
TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival
Nature Communications
author_facet Lele Zhu
Xiaoping Xie
Lingyun Zhang
Hui Wang
Zuliang Jie
Xiaofei Zhou
Jianhong Shi
Shuli Zhao
Boxiang Zhang
Xuhong Cheng
Shao-Cong Sun
author_sort Lele Zhu
title TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival
title_short TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival
title_full TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival
title_fullStr TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival
title_full_unstemmed TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival
title_sort tbk-binding protein 1 regulates il-15-induced autophagy and nkt cell survival
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-07-01
description Interleukin-15 (IL-15) regulates the homeostasis of many immune cell types, including natural killer T (NKT) cells, but the underlying mechanism is not completely clear. Here the authors analyse Tbkbp1-deficient mice and show that IL-15 induces Tbkbp1-dependent autophagy to modulate NKT survival.
url https://doi.org/10.1038/s41467-018-05097-5
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AT xiaopingxie tbkbindingprotein1regulatesil15inducedautophagyandnktcellsurvival
AT lingyunzhang tbkbindingprotein1regulatesil15inducedautophagyandnktcellsurvival
AT huiwang tbkbindingprotein1regulatesil15inducedautophagyandnktcellsurvival
AT zuliangjie tbkbindingprotein1regulatesil15inducedautophagyandnktcellsurvival
AT xiaofeizhou tbkbindingprotein1regulatesil15inducedautophagyandnktcellsurvival
AT jianhongshi tbkbindingprotein1regulatesil15inducedautophagyandnktcellsurvival
AT shulizhao tbkbindingprotein1regulatesil15inducedautophagyandnktcellsurvival
AT boxiangzhang tbkbindingprotein1regulatesil15inducedautophagyandnktcellsurvival
AT xuhongcheng tbkbindingprotein1regulatesil15inducedautophagyandnktcellsurvival
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