Extracellular miR-574-5p Induces Osteoclast Differentiation via TLR 7/8 in Rheumatoid Arthritis

Extracellular miR-574-5p Induces Osteoclast Differentiation via TLR 7/8 in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and joint destruction. Cell-derived small extracellular vesicles (sEV) mediate cell-to-cell communication in the synovial microenvironment by carrying microRNAs (miRs), a class of small non-coding RNAs....

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Bibliographic Details
Main Authors: Anett B. Hegewald, Kai Breitwieser, Sarah M. Ottinger, Fariborz Mobarrez, Marina Korotkova, Bence Rethi, Per-Johan Jakobsson, Anca I. Catrina, Heidi Wähämaa, Meike J. Saul
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
TLR7/8
miR-574-5p
extracellular vesicle (EV)
osteoclast differentiation
rheumatoid arthritis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.585282/full

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