The IRE1α-XBP1s pathway promotes insulin-stimulated glucose uptake in adipocytes by increasing PPARγ activity

Diabetes: Restoring insulin sensitivity Researchers have identified a protein, XBP1s, that may help treat type II diabetes by re-sensitizing cells to insulin. Insulin controls blood sugar levels by triggering cells to absorb sugar from the blood. In obese individuals, cells can lose sensitivity to i...

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Main Authors:	Yoon Mi Cho, Dong Hee Kim, Kyung Hye Lee, Seong-Whan Jeong, Oh-Joo Kwon
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-08-01
Series:	Experimental and Molecular Medicine
Online Access:	https://doi.org/10.1038/s12276-018-0131-0

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spelling	doaj-92a17dfab8134e1aa54f1373a46c021b2020-12-08T13:52:10ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132018-08-0150811510.1038/s12276-018-0131-0The IRE1α-XBP1s pathway promotes insulin-stimulated glucose uptake in adipocytes by increasing PPARγ activityYoon Mi Cho0Dong Hee Kim1Kyung Hye Lee2Seong-Whan Jeong3Oh-Joo Kwon4Department of Biochemistry, College of Medicine, The Catholic University of KoreaDepartment of Biochemistry, College of Medicine, The Catholic University of KoreaDepartment of Biochemistry, College of Medicine, The Catholic University of KoreaDepartment of Biochemistry, College of Medicine, The Catholic University of KoreaDepartment of Biochemistry, College of Medicine, The Catholic University of KoreaDiabetes: Restoring insulin sensitivity Researchers have identified a protein, XBP1s, that may help treat type II diabetes by re-sensitizing cells to insulin. Insulin controls blood sugar levels by triggering cells to absorb sugar from the blood. In obese individuals, cells can lose sensitivity to insulin, requiring increasing quantities to trigger sugar uptake, disrupting blood sugar regulation. Termed insulin resistance, this is a major risk factor for type II diabetes and other diseases. XBP1s was previously known to affect insulin sensitivity, but the mechanism was unclear. Oh-Joo Kwon and co-workers at The Catholic University of Korea in Seoul investigated how XBP1s affected the response of mouse fat cells to insulin. They found that XBP1s restored insulin sensitivity, turning insulin-resistant cells into cells that responded to insulin by absorbing sugar. XBP1s may be useful in treatment or prevention of type II diabetes.https://doi.org/10.1038/s12276-018-0131-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yoon Mi Cho Dong Hee Kim Kyung Hye Lee Seong-Whan Jeong Oh-Joo Kwon
spellingShingle	Yoon Mi Cho Dong Hee Kim Kyung Hye Lee Seong-Whan Jeong Oh-Joo Kwon The IRE1α-XBP1s pathway promotes insulin-stimulated glucose uptake in adipocytes by increasing PPARγ activity Experimental and Molecular Medicine
author_facet	Yoon Mi Cho Dong Hee Kim Kyung Hye Lee Seong-Whan Jeong Oh-Joo Kwon
author_sort	Yoon Mi Cho
title	The IRE1α-XBP1s pathway promotes insulin-stimulated glucose uptake in adipocytes by increasing PPARγ activity
title_short	The IRE1α-XBP1s pathway promotes insulin-stimulated glucose uptake in adipocytes by increasing PPARγ activity
title_full	The IRE1α-XBP1s pathway promotes insulin-stimulated glucose uptake in adipocytes by increasing PPARγ activity
title_fullStr	The IRE1α-XBP1s pathway promotes insulin-stimulated glucose uptake in adipocytes by increasing PPARγ activity
title_full_unstemmed	The IRE1α-XBP1s pathway promotes insulin-stimulated glucose uptake in adipocytes by increasing PPARγ activity
title_sort	ire1α-xbp1s pathway promotes insulin-stimulated glucose uptake in adipocytes by increasing pparγ activity
publisher	Nature Publishing Group
series	Experimental and Molecular Medicine
issn	2092-6413
publishDate	2018-08-01
description	Diabetes: Restoring insulin sensitivity Researchers have identified a protein, XBP1s, that may help treat type II diabetes by re-sensitizing cells to insulin. Insulin controls blood sugar levels by triggering cells to absorb sugar from the blood. In obese individuals, cells can lose sensitivity to insulin, requiring increasing quantities to trigger sugar uptake, disrupting blood sugar regulation. Termed insulin resistance, this is a major risk factor for type II diabetes and other diseases. XBP1s was previously known to affect insulin sensitivity, but the mechanism was unclear. Oh-Joo Kwon and co-workers at The Catholic University of Korea in Seoul investigated how XBP1s affected the response of mouse fat cells to insulin. They found that XBP1s restored insulin sensitivity, turning insulin-resistant cells into cells that responded to insulin by absorbing sugar. XBP1s may be useful in treatment or prevention of type II diabetes.
url	https://doi.org/10.1038/s12276-018-0131-0
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The IRE1α-XBP1s pathway promotes insulin-stimulated glucose uptake in adipocytes by increasing PPARγ activity

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