A Novel Synthesis of Arylpyrrolo[1,2-a]pyrazinone Derivatives

A Novel Synthesis of Arylpyrrolo[1,2-a]pyrazinone Derivatives

Some aryl-2-methyl-1-pyrrolo[1,2-a]pyrazinones were designed and prepared to study the Structure-Activity Relationships (SAR) of pyrrolo[1,2-a]pyrazinone derivatives. With methyl pyrrole-2-carboxylate as the starting material, the title compounds were prepared through N-alkylation and two novel cycl...

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Bibliographic Details
Main Authors: Shoufang Zhang, Jiawei Wang, Fei Wang
Format: Article
Language:English
Published: MDPI AG 2004-06-01
Series:Molecules
Subjects:
Aryl-2-methyl-1-pyrrolo[1
2-a]pyrazinones
synthesis
anti-inflammation.
Online Access:http://www.mdpi.com/1420-3049/9/7/574/
Description
Summary:Some aryl-2-methyl-1-pyrrolo[1,2-a]pyrazinones were designed and prepared to study the Structure-Activity Relationships (SAR) of pyrrolo[1,2-a]pyrazinone derivatives. With methyl pyrrole-2-carboxylate as the starting material, the title compounds were prepared through N-alkylation and two novel cyclizations. Eleven aryl-2-methyl-1- pyrrolo[1,2-a]pyrazinone derivatives not previously reported in the literature are presented in this paper. Some of them show potent anti-inflammatory and analgesic activities.
ISSN:1420-3049

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