Evaluation of in vitro Assays to Assess the Modulation of Dendritic Cells Functions by Therapeutic Antibodies and Aggregates

Evaluation of in vitro Assays to Assess the Modulation of Dendritic Cells Functions by Therapeutic Antibodies and Aggregates

Therapeutic antibodies have the potential to induce immunogenicity leading to the development of anti-drug antibodies (ADA) that consequently may result in reduced serum drug concentrations, a loss of efficacy or potential hypersensitivity reactions. Among other factors, aggregated antibodies have b...

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Bibliographic Details
Main Authors: Hannah Morgan, Su-Yi Tseng, Yann Gallais, Margret Leineweber, Pascale Buchmann, Sabrina Riccardi, Myriam Nabhan, Jeannette Lo, Zaahira Gani, Natacha Szely, Cornelia S. Zhu, Ming Yang, Andrea Kiessling, Hans-Werner Vohr, Marc Pallardy, Fred Aswad, Isabelle Turbica
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
anti-drug antibodies
immunogenicity
dendritic cells
in vitro assays
aggregates
intracellular signaling
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00601/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00601/full

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