A redox-neutral catechol synthesis

Catechols are common structural motifs in bioactive molecules and synthetic building blocks. Here the authors report a method to convert phenol derivatives into catechols via an iridium-catalysed redox-neutral C–H hydroxylation, giving diversely substituted products under mild conditions.

Bibliographic Details
Main Authors:	Qian Wu, Dingyuan Yan, Ying Chen, Ting Wang, Feng Xiong, Wei Wei, Yi Lu, Wei-Yin Sun, Jie Jack Li, Jing Zhao
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms14227

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spelling	doaj-928132b5484e4544bc685b1aa58106ca2021-05-11T07:34:30ZengNature Publishing GroupNature Communications2041-17232017-01-01811910.1038/ncomms14227A redox-neutral catechol synthesisQian Wu0Dingyuan Yan1Ying Chen2Ting Wang3Feng Xiong4Wei Wei5Yi Lu6Wei-Yin Sun7Jie Jack Li8Jing Zhao9Guangdong Key Lab of Nano-Micro Material Research, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate SchoolDepartment of Chemistry, State Key Laboratory of Coordination Chemistry, Institute of Chemistry and BioMedical Sciences, School of Chemistry and Chemical Engineering, Collaborative Innovation Centre of Chemistry for Life Sciences, Nanjing UniversityGuangdong Key Lab of Nano-Micro Material Research, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate SchoolSchool of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate SchoolDepartment of Chemistry, State Key Laboratory of Coordination Chemistry, Institute of Chemistry and BioMedical Sciences, School of Chemistry and Chemical Engineering, Collaborative Innovation Centre of Chemistry for Life Sciences, Nanjing UniversityDepartment of Chemistry, State Key Laboratory of Coordination Chemistry, Institute of Chemistry and BioMedical Sciences, School of Chemistry and Chemical Engineering, Collaborative Innovation Centre of Chemistry for Life Sciences, Nanjing UniversityDepartment of Chemistry, State Key Laboratory of Coordination Chemistry, Institute of Chemistry and BioMedical Sciences, School of Chemistry and Chemical Engineering, Collaborative Innovation Centre of Chemistry for Life Sciences, Nanjing UniversityDepartment of Chemistry, State Key Laboratory of Coordination Chemistry, Institute of Chemistry and BioMedical Sciences, School of Chemistry and Chemical Engineering, Collaborative Innovation Centre of Chemistry for Life Sciences, Nanjing UniversityDepartment of Chemistry, University of San FranciscoGuangdong Key Lab of Nano-Micro Material Research, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate SchoolCatechols are common structural motifs in bioactive molecules and synthetic building blocks. Here the authors report a method to convert phenol derivatives into catechols via an iridium-catalysed redox-neutral C–H hydroxylation, giving diversely substituted products under mild conditions.https://doi.org/10.1038/ncomms14227
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Qian Wu Dingyuan Yan Ying Chen Ting Wang Feng Xiong Wei Wei Yi Lu Wei-Yin Sun Jie Jack Li Jing Zhao
spellingShingle	Qian Wu Dingyuan Yan Ying Chen Ting Wang Feng Xiong Wei Wei Yi Lu Wei-Yin Sun Jie Jack Li Jing Zhao A redox-neutral catechol synthesis Nature Communications
author_facet	Qian Wu Dingyuan Yan Ying Chen Ting Wang Feng Xiong Wei Wei Yi Lu Wei-Yin Sun Jie Jack Li Jing Zhao
author_sort	Qian Wu
title	A redox-neutral catechol synthesis
title_short	A redox-neutral catechol synthesis
title_full	A redox-neutral catechol synthesis
title_fullStr	A redox-neutral catechol synthesis
title_full_unstemmed	A redox-neutral catechol synthesis
title_sort	redox-neutral catechol synthesis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-01-01
description	Catechols are common structural motifs in bioactive molecules and synthetic building blocks. Here the authors report a method to convert phenol derivatives into catechols via an iridium-catalysed redox-neutral C–H hydroxylation, giving diversely substituted products under mild conditions.
url	https://doi.org/10.1038/ncomms14227
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A redox-neutral catechol synthesis

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