Tissue Architecture Influences the Biological Effectiveness of Boron Neutron Capture Therapy in In Vitro/In Silico Three-Dimensional Self-Assembly Cell Models of Pancreatic Cancers

Tissue Architecture Influences the Biological Effectiveness of Boron Neutron Capture Therapy in In Vitro/In Silico Three-Dimensional Self-Assembly Cell Models of Pancreatic Cancers

Pancreatic cancer is a leading cause of cancer death, and boron neutron capture therapy (BNCT) is one of the promising radiotherapy techniques for patients with pancreatic cancer. In this study, we evaluated the biological effectiveness of BNCT at multicellular levels using in vitro and in silico mo...

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Bibliographic Details
Main Authors: Lin-Sheng Yu, Megha Jhunjhunwala, Shiao-Ya Hong, Lin-Yen Yu, Wey-Ran Lin, Chi-Shuo Chen
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
BNCT
3D tumoroid
tumor microenvironment
pancreatic cancer
in silico simulation
cellular potts model
Online Access:https://www.mdpi.com/2072-6694/13/16/4058

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