CyclinG1 Amplification Enhances Aurora Kinase Inhibitor-Induced Polyploid Resistance and Inhibition of Bcl-2 Pathway Reverses the Resistance

CyclinG1 Amplification Enhances Aurora Kinase Inhibitor-Induced Polyploid Resistance and Inhibition of Bcl-2 Pathway Reverses the Resistance

Background/Aims: CyclinG1 (CycG1) is frequently overexpressed in solid tumors and overexpression of CycG1 promotes cell survival upon paclitaxel exposure by inducing polyploidy. Whether and how CycG1 regulates polyploidization caused by small molecular targeted inhibitors remains unclear. Methods: I...

Full description

Bibliographic Details
Main Authors: Wenfeng Zhang, Jie Xu, Dexiang Ji, Zhangyun Li, Wenxing He, Fei Yang, Huiyin Lan, Yu Wang, Zhengping Wu, Xiaoshan Liu, Shanhua Huang, Longkun Li, Weihua Zhou
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
CyclinG1
Polyploidy
Resistance
Bcl-2 family
Targeted therapy
Breast Cancer
Online Access:http://www.karger.com/Article/FullText/480322

Similar Items

Similar Items