RNA Detection in Live Bacterial Cells Using Fluorescent Protein Complementation Triggered by Interaction of Two RNA Aptamers with Two RNA-Binding Peptides

RNA Detection in Live Bacterial Cells Using Fluorescent Protein Complementation Triggered by Interaction of Two RNA Aptamers with Two RNA-Binding Peptides

Many genetic and infectious diseases can be targeted at the RNA level as RNA is more accessible than DNA. We seek to develop new approaches for detection and tracking RNA in live cells, which is necessary for RNA-based diagnostics and therapy. We recently described a method for RNA visualization in...

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Bibliographic Details
Main Authors: Charles R. Cantor, Natalia E. Broude, Paul Toran, Hung-Wei Yiu, Vadim V. Demidov
Format: Article
Language:English
Published: MDPI AG 2011-03-01
Series:Pharmaceuticals
Subjects:
RNA aptamer
fluorescent protein
RNA-binding viral peptide
protein complementation
RNA localization
E. coli cells
Online Access:http://www.mdpi.com/1424-8247/4/3/494/

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