Anti-convulsant therapy in eclampsia.

• Main Authors: Maheshwari J, Desai S, Hansotia M, Walvekar V
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 1989-04-01
• Series: Journal of Postgraduate Medicine
• Subjects: Adult; Anticonvulsants; therapeutic use; Comparative Study; Diazepam; Drug Therapy; Combination; Eclampsia; drug therapy; mortality; Female; Human; Infant Mortality; Magnesium Sulfate; Maternal Mortality; Pentazocine; Phenytoin; Pregnancy
• Online Access: http://www.jpgmonline.com/article.asp?issn=0022-3859;year=1989;volume=35;issue=2;spage=66;epage=9;aulast=Maheshwari
• ISSN: 0022-3859; 0972-2823

Seventy four patients presented with eclampsia at N.W.M. Hospital. Bombay. Among the patients with eclampsia, 64.9% were primis, 29.7% were gravida II-IV and 5.4% were grand multis. As many as 40.5% patients were less than 20 years of age, while 2.7% were over 30 years of age. 48.7% had antepartum convulsions, 40.5% had intrapartum convulsions, while 8 patients convulsed in the postpartum period. Besides standard management of eclamptic patients, 3 protocols of anticonvulsant therapy were utilised. 27% were managed with diphenyl hydantoin sodium, 43% with magnesium sulphate, and 30% by combination of diazepam and pentazocine. The maternal and perinatal outcome was evaluated. Control of convulsions was superior with magnesium sulphate while perinatal outcome was best with diphenyl hydantoin.