Genome-wide DNA methylation analysis in lung fibroblasts co-cultured with silica-exposed alveolar macrophages

Genome-wide DNA methylation analysis in lung fibroblasts co-cultured with silica-exposed alveolar macrophages

Abstract Background Exposure to crystalline silica is considered to increase the risk of lung fibrosis. The primary effector cell, the myofibroblast, plays an important role in the deposition of extracellular matrix (ECM). DNA methylation change is considered to have a potential effect on myofibrobl...

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Bibliographic Details
Main Authors: Juan Li, Wu Yao, Lin Zhang, Lei Bao, Huiting Chen, Di Wang, Zhongzheng Yue, Yiping Li, Miao Zhang, Changfu Hao
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Respiratory Research
Subjects:
Fibroblast
Crystalline silica
Methylation
Differentiation
Online Access:http://link.springer.com/article/10.1186/s12931-017-0576-z

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