Methyl 2-(1-methyl-3-oxoisoindolin-1-yl)acetate

Methyl 2-(1-methyl-3-oxoisoindolin-1-yl)acetate

In this work, we report a facile access to a 3,3-disubstituted isoindolinone by means of Krapcho decarboxylation reaction of the respective substituted dimethyl malonate derivative. Good isolated yields were obtained under mild reaction conditions.

Bibliographic Details
Main Authors: Antonia Di Mola, Antonio Macchia, Laura Palombi, Antonio Massa
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Molbank
Subjects:
isoindolinone
quaternary carbon
Krapcho reaction
Online Access:https://www.mdpi.com/1422-8599/2020/2/M1131
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spelling doaj-925f049bf88344e3a45091dc3522ded92020-11-25T02:04:17ZengMDPI AGMolbank1422-85992020-05-012020M1131M113110.3390/M1131Methyl 2-(1-methyl-3-oxoisoindolin-1-yl)acetateAntonia Di Mola0Antonio Macchia1Laura Palombi2Antonio Massa3Department of Chemistry and Biology, University of Salerno, Via Giovanni Paolo II, 84084 Fisciano (SA), ItalyDepartment of Chemistry and Biology, University of Salerno, Via Giovanni Paolo II, 84084 Fisciano (SA), ItalyDepartment of Physical and Chemical Sciences, University of L’Aquila, via Vetoio, 67100 Coppito (AQ), ItalyDepartment of Chemistry and Biology, University of Salerno, Via Giovanni Paolo II, 84084 Fisciano (SA), ItalyIn this work, we report a facile access to a 3,3-disubstituted isoindolinone by means of Krapcho decarboxylation reaction of the respective substituted dimethyl malonate derivative. Good isolated yields were obtained under mild reaction conditions.https://www.mdpi.com/1422-8599/2020/2/M1131isoindolinonequaternary carbonKrapcho reaction
collection DOAJ
language English
format Article
sources DOAJ
author Antonia Di Mola
Antonio Macchia
Laura Palombi
Antonio Massa
spellingShingle Antonia Di Mola
Antonio Macchia
Laura Palombi
Antonio Massa
Methyl 2-(1-methyl-3-oxoisoindolin-1-yl)acetate
Molbank
isoindolinone
quaternary carbon
Krapcho reaction
author_facet Antonia Di Mola
Antonio Macchia
Laura Palombi
Antonio Massa
author_sort Antonia Di Mola
title Methyl 2-(1-methyl-3-oxoisoindolin-1-yl)acetate
title_short Methyl 2-(1-methyl-3-oxoisoindolin-1-yl)acetate
title_full Methyl 2-(1-methyl-3-oxoisoindolin-1-yl)acetate
title_fullStr Methyl 2-(1-methyl-3-oxoisoindolin-1-yl)acetate
title_full_unstemmed Methyl 2-(1-methyl-3-oxoisoindolin-1-yl)acetate
title_sort methyl 2-(1-methyl-3-oxoisoindolin-1-yl)acetate
publisher MDPI AG
series Molbank
issn 1422-8599
publishDate 2020-05-01
description In this work, we report a facile access to a 3,3-disubstituted isoindolinone by means of Krapcho decarboxylation reaction of the respective substituted dimethyl malonate derivative. Good isolated yields were obtained under mild reaction conditions.
topic isoindolinone
quaternary carbon
Krapcho reaction
url https://www.mdpi.com/1422-8599/2020/2/M1131
work_keys_str_mv AT antoniadimola methyl21methyl3oxoisoindolin1ylacetate
AT antoniomacchia methyl21methyl3oxoisoindolin1ylacetate
AT laurapalombi methyl21methyl3oxoisoindolin1ylacetate
AT antoniomassa methyl21methyl3oxoisoindolin1ylacetate
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