Four New Cyclohexylideneacetonitrile Derivatives from the Hypocotyl of Mangrove (Bruguiera gymnorrhiza)

Four New Cyclohexylideneacetonitrile Derivatives from the Hypocotyl of Mangrove (Bruguiera gymnorrhiza)

Four new cyclohexylideneacetonitrile derivatives 1–4, named menisdaurins B–E, as well as three known cyclohexylideneacetonitrile derivatives—menisdaurin (5), coclauril (6), and menisdaurilide (7)—were isolated from the hypocotyl of a mangrove (Bruguiera gymnorrhiza). The structures of the isolates...

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Bibliographic Details
Main Authors: Xiang-Xi Yi, Jia-Gang Deng, Cheng-Hai Gao, Xiao-Tao Hou, Fei Li, Zhi-Ping Wang, Er-Wei Hao, Yan Xie, Zheng-Cai Du, Hui-Xue Huang, Ri-Ming Huang
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:Molecules
Subjects:
antiviral
Bruguiera gymnorrhiza
cyclohexylideneacetonitrile derivative
Online Access:http://www.mdpi.com/1420-3049/20/8/14565
Description
Summary:Four new cyclohexylideneacetonitrile derivatives 1–4, named menisdaurins B–E, as well as three known cyclohexylideneacetonitrile derivatives—menisdaurin (5), coclauril (6), and menisdaurilide (7)—were isolated from the hypocotyl of a mangrove (Bruguiera gymnorrhiza). The structures of the isolates were elucidated on the basis of extensive spectroscopic analysis. Compounds 1–7 showed anti-Hepatitis B virus (HBV) activities, with EC50 values ranging from 5.1 ± 0.2 μg/mL to 87.7 ± 5.8 μg/mL.
ISSN:1420-3049

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