Metformin, an AMPK Activator, Inhibits Activation of FLSs but Promotes HAPLN1 Secretion

Metformin, an AMPK Activator, Inhibits Activation of FLSs but Promotes HAPLN1 Secretion

AMP-activated protein kinase (AMPK) is essential for maintaining energy balance and has a crucial role in various inflammatory pathways. In this study, AMPK levels positively correlated with many inflammatory indexes in rheumatoid arthritis (RA) patients, especially in the affected synovium. In RA s...

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Bibliographic Details
Main Authors: Yong Chen, Fujuan Qiu, Beijia Yu, Yanjuan Chen, Fangfang Zuo, XiaoYu Zhu, Kutty Selva Nandakumar, Changhong Xiao
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
rheumatoid arthritis
disease activity
metabolism
AMP-activated protein kinase
fibroblast-like synoviocyte
metformin
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120300954

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http://www.sciencedirect.com/science/article/pii/S2329050120300954

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