Polymorphisms in folate-metabolizing genes, chromosome damage, and risk of Down syndrome in Italian women: identification of key factors using artificial neural networks

<p>Abstract</p> <p>Background</p> <p>Studies in mothers of Down syndrome individuals (MDS) point to a role for polymorphisms in folate metabolic genes in increasing chromosome damage and maternal risk for a Down syndrome (DS) pregnancy, suggesting complex gene-gene inte...

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Bibliographic Details
Main Authors: Migheli Francesca, Grossi Enzo, Coppedè Fabio, Migliore Lucia
Format: Article
Language:English
Published: BMC 2010-09-01
Series:BMC Medical Genomics
Online Access:http://www.biomedcentral.com/1755-8794/3/42