Effects of delta-Aminolevulinic Acid Dehydratase Gene Polymorphism on Hematological Parameters and Kidney Function of Lead-exposed Workers

• Main Authors: Mona Sobhi Siha, Dalia Abdel-Hamid Shaker, Hebatalla Saad Teleb, Laila Ahmed Rashed
• Format: Article
• Language: English
• Published: National Iranian Oil Company (NIOC) Health Organization 2019-04-01
• Series: The International Journal of Occupational and Environmental Medicine
• Subjects: Explosive agents; Lead; Porphobilinogen synthase; Polymorphism, genetic; beta 2-Microglobulin
• Online Access: http://www.theijoem.com/ijoem/index.php/ijoem/article/view/1629

Lead exposure is associated with several health hazards among workers with different individual responses. We conducted this study to determine the possible effects of lead exposure on hematological parameters and kidney function of a group of Egyptian ammunition workers and the interaction of aminolevulinic acid dehydratase (ALAD) G177C gene polymorphisms as an effect modifier. Significant differences were observed between exposed workers with ALAD1-1 and ALAD1-2 genotypes in terms of blood lead level, hematological parameters and kidney function. It seems that δ-ALAD gene polymorphism may be an effect modifier and a marker of genetic susceptibility to lead toxicity.