Hederagenin Attenuates Cerebral Ischaemia/Reperfusion Injury by Regulating MLK3 Signalling

Hederagenin Attenuates Cerebral Ischaemia/Reperfusion Injury by Regulating MLK3 Signalling

Cerebral ischaemia/reperfusion (CI/R) injury is a major challenge due to the lack of effective neuroprotective drugs. Hederagenin (HE) is the aglycone part of saponins extracted from Hedera helix Linné that has exhibited anti-apoptotic and anti-inflammatory effects; however, the role of HE in CI/R h...

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Bibliographic Details
Main Authors: Hailong Yu, Lilong Song, Xiang Cao, Wei Li, Yuanyuan Zhao, Jian Chen, Jun Li, Yingzhu Chen, Wenkui Yu, Yun Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Pharmacology
Subjects:
cerebral ischaemia/reperfusion injury
hederagenin
apoptosis
inflammation
MLK3 signalling pathway
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01173/full

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