Gastroretentive raft liquid delivery system as a new approach to release extension for carrier-mediated drug

Gastroretentive raft liquid delivery system as a new approach to release extension for carrier-mediated drug

Gabapentin (GBP), an antiepileptic and anti-neuropathic agent, suffers from short half-life (5–7 h), has narrow absorption window, and is absorbed via carrier-mediated mechanism resulting in frequent dosing, poor compliance, and poor bioavailability (<60%). Moreover, GBP is a freely water-soluble...

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Bibliographic Details
Main Authors: Samar M. Abouelatta, Ahmed A. Aboelwafa, Omaima N. El-Gazayerly
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Drug Delivery
Subjects:
gabapentin
raft forming systems
gmo
lm-pectin 101
gellan gum
Online Access:http://dx.doi.org/10.1080/10717544.2018.1474969

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