An Exploratory Association Analysis of <i>ABCB</i><sub>1</sub> rs1045642 and <i>ABCB</i><sub>1</sub> rs4148738 with Non-Major Bleeding Risk in Atrial Fibrillation Patients Treated with Dabigatran or Apixaban

An Exploratory Association Analysis of <i>ABCB</i><sub>1</sub> rs1045642 and <i>ABCB</i><sub>1</sub> rs4148738 with Non-Major Bleeding Risk in Atrial Fibrillation Patients Treated with Dabigatran or Apixaban

(1) Background: The approach of bleeding complications in patients treated with non-vitamin K oral anticoagulants (NOACs) represents an important issue in clinical practice. Both dabigatran and apixaban are substrates for P-glycoprotein and, therefore, <i>ABCB</i><sub>1</sub>...

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Main Authors: Adela-Nicoleta Roşian, Mihaela Iancu, Adrian Pavel Trifa, Ştefan Horia Roşian, Cristina Mada, Cornelia Paula Gocan, Teodora Niţă, Sabina Istratoaie, Paul-Mihai Boarescu, Anca Dana Buzoianu
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Journal of Personalized Medicine
Subjects:
<i>ABCB</i><sub>1</sub>
apixaban
bleedings
clinical practice
dabigatran
pharmacogenomics
Online Access:https://www.mdpi.com/2075-4426/10/3/133

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