Bone mineral density in children with long-term antiepileptic therapy
Introduction. Vitamin D active metabolites deficit that is altered by negative calcium and phosphorus balance is a potential complication during longterm antiepileptic drug therapy. Objective. The aim of this study was to examine lumbar bone mineral density (BMD) in epileptic children receiving...
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Serbian Medical Society
2013-01-01
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Online Access: | http://www.doiserbia.nb.rs/img/doi/0370-8179/2013/0370-81791306329D.pdf |
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doaj-91fd0b7f1a354dcfae54d36cf1e5a3b02021-01-02T06:58:41ZengSerbian Medical SocietySrpski Arhiv za Celokupno Lekarstvo0370-81792013-01-011415-632933210.2298/SARH1306329DBone mineral density in children with long-term antiepileptic therapyDimić MilenaDimić AleksandarMilošević ZoranVojinović JelenaIntroduction. Vitamin D active metabolites deficit that is altered by negative calcium and phosphorus balance is a potential complication during longterm antiepileptic drug therapy. Objective. The aim of this study was to examine lumbar bone mineral density (BMD) in epileptic children receiving antiepileptic drug therapy longer than one year. methods. The examined sample consisted of 34 epileptic children, 18 male and 16 female, aged 612 (9.77±2.01) years, treated with carbamazepine, valproate, phenobarbital, lamotrigine or their combination without vitamin D supplementation. The lumbar spine BMD (L1L4) was estimated by a Lunar densitometer and obtained results were compared with results of 35 matched population of healthy children from the control group. results. Lumbar BMD Zscore was significantly lower in female patients treated with antiepileptic therapy compared with those in the control group (1.048±1.35 vs. 0.399±0.518; p=0.03). Bone mineral density Zscore decrease of both gender groups receiving antiepileptic polytherapy was significantly lower compared to the control group (1.153±0.938 vs. 0.043±0.815; p=0.007). Therapy duration had no influence on the lumbar BMD level decrease either in boys (rxy=0.33; p=0.174) or in girls (rxy=0.02; p=0.935) treated with antiepileptic therapy. Conclusion. Our results have indicated that antiepileptic drug therapy usage longer than one year can have adverse affects on the lumbar spine BMD (L1L4) in epileptic children, and that prophylactic vitamin D supplementation is also necessary in these patients.http://www.doiserbia.nb.rs/img/doi/0370-8179/2013/0370-81791306329D.pdfbone mineral densityantiepileptic therapychildren |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dimić Milena Dimić Aleksandar Milošević Zoran Vojinović Jelena |
spellingShingle |
Dimić Milena Dimić Aleksandar Milošević Zoran Vojinović Jelena Bone mineral density in children with long-term antiepileptic therapy Srpski Arhiv za Celokupno Lekarstvo bone mineral density antiepileptic therapy children |
author_facet |
Dimić Milena Dimić Aleksandar Milošević Zoran Vojinović Jelena |
author_sort |
Dimić Milena |
title |
Bone mineral density in children with long-term antiepileptic therapy |
title_short |
Bone mineral density in children with long-term antiepileptic therapy |
title_full |
Bone mineral density in children with long-term antiepileptic therapy |
title_fullStr |
Bone mineral density in children with long-term antiepileptic therapy |
title_full_unstemmed |
Bone mineral density in children with long-term antiepileptic therapy |
title_sort |
bone mineral density in children with long-term antiepileptic therapy |
publisher |
Serbian Medical Society |
series |
Srpski Arhiv za Celokupno Lekarstvo |
issn |
0370-8179 |
publishDate |
2013-01-01 |
description |
Introduction. Vitamin D active metabolites deficit that is altered by negative calcium and phosphorus balance is a potential complication during longterm antiepileptic drug therapy. Objective. The aim of this study was to examine lumbar bone mineral density (BMD) in epileptic children receiving antiepileptic drug therapy longer than one year. methods. The examined sample consisted of 34 epileptic children, 18 male and 16 female, aged 612 (9.77±2.01) years, treated with carbamazepine, valproate, phenobarbital, lamotrigine or their combination without vitamin D supplementation. The lumbar spine BMD (L1L4) was estimated by a Lunar densitometer and obtained results were compared with results of 35 matched population of healthy children from the control group. results. Lumbar BMD Zscore was significantly lower in female patients treated with antiepileptic therapy compared with those in the control group (1.048±1.35 vs. 0.399±0.518; p=0.03). Bone mineral density Zscore decrease of both gender groups receiving antiepileptic polytherapy was significantly lower compared to the control group (1.153±0.938 vs. 0.043±0.815; p=0.007). Therapy duration had no influence on the lumbar BMD level decrease either in boys (rxy=0.33; p=0.174) or in girls (rxy=0.02; p=0.935) treated with antiepileptic therapy. Conclusion. Our results have indicated that antiepileptic drug therapy usage longer than one year can have adverse affects on the lumbar spine BMD (L1L4) in epileptic children, and that prophylactic vitamin D supplementation is also necessary in these patients. |
topic |
bone mineral density antiepileptic therapy children |
url |
http://www.doiserbia.nb.rs/img/doi/0370-8179/2013/0370-81791306329D.pdf |
work_keys_str_mv |
AT dimicmilena bonemineraldensityinchildrenwithlongtermantiepileptictherapy AT dimicaleksandar bonemineraldensityinchildrenwithlongtermantiepileptictherapy AT miloseviczoran bonemineraldensityinchildrenwithlongtermantiepileptictherapy AT vojinovicjelena bonemineraldensityinchildrenwithlongtermantiepileptictherapy |
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