Bone mineral density in children with long-term antiepileptic therapy

Introduction. Vitamin D active metabolites deficit that is altered by negative calcium and phosphorus balance is a potential complication during long­term antiepileptic drug therapy. Objective. The aim of this study was to examine lumbar bone mineral density (BMD) in epileptic children receiving...

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Main Authors: Dimić Milena, Dimić Aleksandar, Milošević Zoran, Vojinović Jelena
Format: Article
Language:English
Published: Serbian Medical Society 2013-01-01
Series:Srpski Arhiv za Celokupno Lekarstvo
Subjects:
Online Access:http://www.doiserbia.nb.rs/img/doi/0370-8179/2013/0370-81791306329D.pdf
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spelling doaj-91fd0b7f1a354dcfae54d36cf1e5a3b02021-01-02T06:58:41ZengSerbian Medical SocietySrpski Arhiv za Celokupno Lekarstvo0370-81792013-01-011415-632933210.2298/SARH1306329DBone mineral density in children with long-term antiepileptic therapyDimić MilenaDimić AleksandarMilošević ZoranVojinović JelenaIntroduction. Vitamin D active metabolites deficit that is altered by negative calcium and phosphorus balance is a potential complication during long­term antiepileptic drug therapy. Objective. The aim of this study was to examine lumbar bone mineral density (BMD) in epileptic children receiving antiepileptic drug therapy longer than one year. methods. The examined sample consisted of 34 epileptic children, 18 male and 16 female, aged 6­12 (9.77±2.01) years, treated with carbamazepine, valproate, phenobarbital, lamotrigine or their combination without vitamin D supplementation. The lumbar spine BMD (L1­L4) was estimated by a Lunar densitometer and obtained results were compared with results of 35 matched population of healthy children from the control group. results. Lumbar BMD Z­score was significantly lower in female patients treated with antiepileptic therapy compared with those in the control group (­1.048±1.35 vs. ­0.399±0.518; p=0.03). Bone mineral density Z­score decrease of both gender groups receiving antiepileptic polytherapy was significantly lower compared to the control group (­1.153±0.938 vs. ­0.043±0.815; p=0.007). Therapy duration had no influence on the lumbar BMD level decrease either in boys (rxy=0.33; p=0.174) or in girls (rxy=0.02; p=0.935) treated with antiepileptic therapy. Conclusion. Our results have indicated that antiepileptic drug therapy usage longer than one year can have adverse affects on the lumbar spine BMD (L1­L4) in epileptic children, and that prophylactic vitamin D supplementation is also necessary in these patients.http://www.doiserbia.nb.rs/img/doi/0370-8179/2013/0370-81791306329D.pdfbone mineral densityantiepileptic therapychildren
collection DOAJ
language English
format Article
sources DOAJ
author Dimić Milena
Dimić Aleksandar
Milošević Zoran
Vojinović Jelena
spellingShingle Dimić Milena
Dimić Aleksandar
Milošević Zoran
Vojinović Jelena
Bone mineral density in children with long-term antiepileptic therapy
Srpski Arhiv za Celokupno Lekarstvo
bone mineral density
antiepileptic therapy
children
author_facet Dimić Milena
Dimić Aleksandar
Milošević Zoran
Vojinović Jelena
author_sort Dimić Milena
title Bone mineral density in children with long-term antiepileptic therapy
title_short Bone mineral density in children with long-term antiepileptic therapy
title_full Bone mineral density in children with long-term antiepileptic therapy
title_fullStr Bone mineral density in children with long-term antiepileptic therapy
title_full_unstemmed Bone mineral density in children with long-term antiepileptic therapy
title_sort bone mineral density in children with long-term antiepileptic therapy
publisher Serbian Medical Society
series Srpski Arhiv za Celokupno Lekarstvo
issn 0370-8179
publishDate 2013-01-01
description Introduction. Vitamin D active metabolites deficit that is altered by negative calcium and phosphorus balance is a potential complication during long­term antiepileptic drug therapy. Objective. The aim of this study was to examine lumbar bone mineral density (BMD) in epileptic children receiving antiepileptic drug therapy longer than one year. methods. The examined sample consisted of 34 epileptic children, 18 male and 16 female, aged 6­12 (9.77±2.01) years, treated with carbamazepine, valproate, phenobarbital, lamotrigine or their combination without vitamin D supplementation. The lumbar spine BMD (L1­L4) was estimated by a Lunar densitometer and obtained results were compared with results of 35 matched population of healthy children from the control group. results. Lumbar BMD Z­score was significantly lower in female patients treated with antiepileptic therapy compared with those in the control group (­1.048±1.35 vs. ­0.399±0.518; p=0.03). Bone mineral density Z­score decrease of both gender groups receiving antiepileptic polytherapy was significantly lower compared to the control group (­1.153±0.938 vs. ­0.043±0.815; p=0.007). Therapy duration had no influence on the lumbar BMD level decrease either in boys (rxy=0.33; p=0.174) or in girls (rxy=0.02; p=0.935) treated with antiepileptic therapy. Conclusion. Our results have indicated that antiepileptic drug therapy usage longer than one year can have adverse affects on the lumbar spine BMD (L1­L4) in epileptic children, and that prophylactic vitamin D supplementation is also necessary in these patients.
topic bone mineral density
antiepileptic therapy
children
url http://www.doiserbia.nb.rs/img/doi/0370-8179/2013/0370-81791306329D.pdf
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