New ibuprofen derivatives with thiazolidine-4-one scaffold with improved pharmaco-toxicological profile

New ibuprofen derivatives with thiazolidine-4-one scaffold with improved pharmaco-toxicological profile

Abstract Background Aryl-propionic acid derivatives with ibuprofen as representative drug are very important for therapy, being recommended especially for anti-inflammatory and analgesic effects. On other hand 1,3-thiazolidine-4-one scaffold is an important heterocycle, which is associated with diff...

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Bibliographic Details
Main Authors: Ioana-Mirela Vasincu, Maria Apotrosoaei, Sandra Constantin, Maria Butnaru, Liliana Vereștiuc, Cătălina-Elena Lupușoru, Frederic Buron, Sylvain Routier, Dan Lupașcu, Roxana-Georgiana Taușer, Lenuța Profire
Format: Article
Language:English
Published: BMC 2021-02-01
Series:BMC Pharmacology and Toxicology
Subjects:
Ibuprofen
Thiazolidine-4-one
Toxicity degree
Anti-inflammatory and analgesic effects
Online Access:https://doi.org/10.1186/s40360-021-00475-0

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