A brief summary of human molecular genetic techniques for clinical psychiatrists
Concerted and systematic efforts to understand genetics of human health and disease over the preceding 60 odd years have witnessed remarkable progress. The incremental gains through this journey were enabled by chromosomal analysis, recombinant deoxyribonucleic acid (DNA) techniques, notable discove...
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doaj-91f46a52b63346b5bd928f072f7e4e2f2021-01-26T06:42:42ZengAcademy PublisherOpen Journal of Psychiatry and Allied Sciences2394-20532394-20612021-01-01121556110.5958/2394-2061.2021.00010.0A brief summary of human molecular genetic techniques for clinical psychiatristsChandra Bhushan Rai0Anirban Mukhopadhyay1Smita N Deshpande2BK Thelma3Department of Psychiatry, Centre of Excellence in Mental Health, Atal Bihari Vajpayee Institute of Medical Sciences & Dr. Ram Manohar Lohia Hospital, New Delhi-110001, IndiaDepartment of Genetics, University of Delhi South Campus, New Delhi-110021, IndiaDepartment of Psychiatry, Centre of Excellence in Mental Health, Atal Bihari Vajpayee Institute of Medical Sciences & Dr. Ram Manohar Lohia Hospital, New Delhi-110001, IndiaDepartment of Genetics, University of Delhi South Campus, New Delhi-110021, IndiaConcerted and systematic efforts to understand genetics of human health and disease over the preceding 60 odd years have witnessed remarkable progress. The incremental gains through this journey were enabled by chromosomal analysis, recombinant deoxyribonucleic acid (DNA) techniques, notable discovery of single nucleotide polymorphisms following the Human Genome Project, consequent genome-wide variant-based studies, and now whole genome sequencing with ultimate diagnostic potential. Of note, success in prediction and prevention of chromosomal and single gene disorders comprising ~six to eight per cent each of all genetic disorders have been unprecedented but uncovering genetics of common complex disorders conferring ~60% of the genetic disease burden continues to pose a challenge and await new analytical paradigms - a mix of reductionist and organismal biology together with artificial intelligence and machine learning approaches being the current trend. A brief account of this path of progress in medical genetics and genomic insights along with limitations, to achieve the overarching goals of predictive, preventive, personalised, and participatory medicine is presented in this article.https://www.ojpas.com/get_file.php?id=34209994&vnr=398173genegenomicsclinicalmedicine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chandra Bhushan Rai Anirban Mukhopadhyay Smita N Deshpande BK Thelma |
spellingShingle |
Chandra Bhushan Rai Anirban Mukhopadhyay Smita N Deshpande BK Thelma A brief summary of human molecular genetic techniques for clinical psychiatrists Open Journal of Psychiatry and Allied Sciences gene genomics clinical medicine |
author_facet |
Chandra Bhushan Rai Anirban Mukhopadhyay Smita N Deshpande BK Thelma |
author_sort |
Chandra Bhushan Rai |
title |
A brief summary of human molecular genetic techniques for clinical psychiatrists |
title_short |
A brief summary of human molecular genetic techniques for clinical psychiatrists |
title_full |
A brief summary of human molecular genetic techniques for clinical psychiatrists |
title_fullStr |
A brief summary of human molecular genetic techniques for clinical psychiatrists |
title_full_unstemmed |
A brief summary of human molecular genetic techniques for clinical psychiatrists |
title_sort |
brief summary of human molecular genetic techniques for clinical psychiatrists |
publisher |
Academy Publisher |
series |
Open Journal of Psychiatry and Allied Sciences |
issn |
2394-2053 2394-2061 |
publishDate |
2021-01-01 |
description |
Concerted and systematic efforts to understand genetics of human health and disease over the preceding 60 odd years have witnessed remarkable progress. The incremental gains through this journey were enabled by chromosomal analysis, recombinant deoxyribonucleic acid (DNA) techniques, notable discovery of single nucleotide polymorphisms following the Human Genome Project, consequent genome-wide variant-based studies, and now whole genome sequencing with ultimate diagnostic potential. Of note, success in prediction and prevention of chromosomal and single gene disorders comprising ~six to eight per cent each of all genetic disorders have been unprecedented but uncovering genetics of common complex disorders conferring ~60% of the genetic disease burden continues to pose a challenge and await new analytical paradigms - a mix of reductionist and organismal biology together with artificial intelligence and machine learning approaches being the current trend. A brief account of this path of progress in medical genetics and genomic insights along with limitations, to achieve the overarching goals of predictive, preventive, personalised, and participatory medicine is presented in this article. |
topic |
gene genomics clinical medicine |
url |
https://www.ojpas.com/get_file.php?id=34209994&vnr=398173 |
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