Shielding of Lipid Nanoparticles for siRNA Delivery: Impact on Physicochemical Properties, Cytokine Induction, and Efficacy

Shielding of Lipid Nanoparticles for siRNA Delivery: Impact on Physicochemical Properties, Cytokine Induction, and Efficacy

Formulation of short interfering RNA (siRNA) into multicomponent lipid nanoparticles (LNP) is an effective strategy for hepatic delivery and therapeutic gene silencing. This study systematically evaluated the effect of polyethylene glycol (PEG) density on LNP physicochemical properties, innate immun...

Full description

Bibliographic Details
Main Authors: Varun Kumar, June Qin, Yongfeng Jiang, Richard G Duncan, Benjamin Brigham, Shannon Fishman, Jayaprakash K Nair, Akin Akinc, Scott A Barros, Pia V Kasperkovitz
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
delivery
immune response
nanomedicine
nanoparticles
polyethylene glycol
RNAi
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116303493

Internet

http://www.sciencedirect.com/science/article/pii/S2162253116303493

Similar Items