Drug-induced atypical hyperplasia enveloping salivary gland malignancy

• Main Authors: Anjali Narwal, Virender Singh, Shashi Bala
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2017-01-01
• Series: Journal of Indian Society of Periodontology
• Subjects: Amlodipine; calcium channel blocker; mucoepidermoid carcinoma
• Online Access: http://www.jisponline.com/article.asp?issn=0972-124X;year=2017;volume=21;issue=5;spage=409;epage=411;aulast=Narwal

Gingival enlargement is a very common side effect associated with the administration of several drugs, mainly anticonvulsants, calcium channel blockers (CCBs), and immunosuppressants. Amlodipine (a CCB) is a safe antihypertensive drug with a longer duration of action. Gingival enlargement induced by amlodipine is less prevalent among CCBs. Since the pathogenesis is not well understood, it is still a challenge for clinicians to diagnose and manage cases effectively. This case presents an atypical unilateral palatal gingival enlargement in a 61-year-old hypertensive female taking amlodipine. Difficulty for a pathologist in diagnosing in spite of repeated sample submission from the lesion and repeated failure for the operator to reach the underlying pathology due to amlodipine-induced hyperplasia have also been discussed in this case report.