Inactivation of the PD-1-Dependent Immunoregulation in Mice Exacerbates Contact Hypersensitivity Resembling Immune-Related Adverse Events

Inactivation of the PD-1-Dependent Immunoregulation in Mice Exacerbates Contact Hypersensitivity Resembling Immune-Related Adverse Events

Blockade of PD-1, an indispensable physiological immunoregulatory mechanism, enhances immune activities and is widely used in the immunotherapy of cancer. This treatment often accompanies inflammatory complication called immune-related adverse events (irAE), most frequently in the skin. To analyze h...

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Bibliographic Details
Main Authors: Matin Dokht Ashoori, Kensuke Suzuki, Yosuke Tokumaru, Naoko Ikuta, Masaki Tajima, Tasuku Honjo, Akio Ohta
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
PD-1
cancer immunotherapy
immune-related adverse events
contact hypersensitivity
skin
T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.618711/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.618711/full

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