NEK2 Promotes Aerobic Glycolysis in Multiple Myeloma Through Regulating Splicing of Pyruvate Kinase

NEK2 Promotes Aerobic Glycolysis in Multiple Myeloma Through Regulating Splicing of Pyruvate Kinase

Abstract Background Aerobic glycolysis, a hallmark of cancer, is characterized by increased metabolism of glucose and production of lactate in normaxia. Recently, pyruvate kinase M2 (PKM2) has been identified as a key player for regulating aerobic glycolysis and promoting tumor cell proliferation an...

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Bibliographic Details
Main Authors: Zhimin Gu, Jiliang Xia, Hongwei Xu, Ivana Frech, Guido Tricot, Fenghuang Zhan
Format: Article
Language:English
Published: BMC 2017-01-01
Series:Journal of Hematology & Oncology
Subjects:
NEK2
Pyruvate kinase
Multiple myeloma
Alternative splicing
Online Access:http://link.springer.com/article/10.1186/s13045-017-0392-4

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