A Novel Convergent Synthesis of the Potent Antiglaucoma Agent Tafluprost

A Novel Convergent Synthesis of the Potent Antiglaucoma Agent Tafluprost

Tafluprost (AFP-168, 5) is a unique 15-deoxy-15,15-difluoro-16-phenoxy prostaglandin F2α (PGF2α) analog used as an efficacious ocular hypotensive agent in the treatment of glaucoma and ocular hypertension, as monotherapy, or as adjunctive therapy to β-blockers. A novel convergent synthesis of 5 was...

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Bibliographic Details
Main Authors: Małgorzata Krupa, Michał Chodyński, Anna Ostaszewska, Piotr Cmoch, Iwona Dams
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:Molecules
Subjects:
tafluprost
prostaglandins
Corey lactone
Julia–Lythgoe olefination
fluorination
Online Access:http://www.mdpi.com/1420-3049/22/2/217

Internet

http://www.mdpi.com/1420-3049/22/2/217

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