Structure–Activity Relationships of the Tetrapeptide Ac-His-Arg-(<i>p</i>I)DPhe-Tic-NH<sub>2</sub> at the Mouse Melanocortin Receptors: Modification at the (<i>p</i>I)DPhe Position Leads to mMC3R Versus mMC4R Selective Ligands

Structure–Activity Relationships of the Tetrapeptide Ac-His-Arg-(<i>p</i>I)DPhe-Tic-NH<sub>2</sub> at the Mouse Melanocortin Receptors: Modification at the (<i>p</i>I)DPhe Position Leads to mMC3R Versus mMC4R Selective Ligands

The five melanocortin receptors (MC1R&#8211;MC5R) are involved in numerous biological pathways, including steroidogenesis, pigmentation, and food intake. In particular, MC3R and MC4R knockout mice suggest that the MC3R and MC4R regulate energy homeostasis in a non-redundant manner. While MC4R-se...

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Bibliographic Details
Main Authors: Katherine N. Schlasner, Mark D. Ericson, Skye R. Doering, Katie T. Freeman, Mary Weinrich, Carrie Haskell-Luevano
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Molecules
Subjects:
MC3R
MC4R
mixed pharmacology
tetrapeptides
melanocortins
Online Access:https://www.mdpi.com/1420-3049/24/8/1463

Internet

https://www.mdpi.com/1420-3049/24/8/1463

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