MiR-143-3p Inhibits Osteogenic Differentiation of Human Periodontal Ligament Cells by Targeting KLF5 and Inactivating the Wnt/β-Catenin Pathway

MiR-143-3p Inhibits Osteogenic Differentiation of Human Periodontal Ligament Cells by Targeting KLF5 and Inactivating the Wnt/β-Catenin Pathway

Human periodontal ligament cells (hPDLCs) play a vital role in cell regeneration and tissue repair with multi-directional differentiation potential. microRNAs (miRs) are implicated in the osteogenesis of hPDLCs. This study explored the mechanism of miR-143-3p in osteogenesis of hPDLCs. Osteogenic di...

Full description

Bibliographic Details
Main Authors:	Kaixin Wangzhou, Zhiying Lai, Zishao Lu, Wanren Fu, Cheng Liu, Zhengeng Liang, Yi Tan, Conghui Li, Chunbo Hao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-02-01
Series:	Frontiers in Physiology
Subjects:	human periodontal ligament cells osteogenic differentiation microRNA-143-3p KLF5 Wnt/β-catenin pathway
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2020.606967/full

Similar Items

Andrographolide Exerts Pro-Osteogenic Effect by Activation of Wnt/β-Catenin Signaling Pathway in Vitro
by: Tongmeng Jiang, et al.
Published: (2015-07-01)

KLF8 Promotes Temozolomide Resistance in Glioma Cells via β-Catenin Activation
by: Guo Yu, et al.
Published: (2016-04-01)

Down-regulation of LECT2 promotes osteogenic differentiation of MSCs via activating Wnt/β-catenin pathway
by: Zhonghua Xu, et al.
Published: (2020-10-01)

Epigenetic silencing of KLF2 by long non-coding RNA SNHG1 inhibits periodontal ligament stem cell osteogenesis differentiation
by: Zhaobao Li, et al.
Published: (2020-10-01)

Salidroside promoted osteogenic differentiation of adipose-derived stromal cells through Wnt/β-catenin signaling pathway
by: Xiao-hua Li, et al.
Published: (2021-07-01)

MicroRNA-197-3p Inhibits the Osteogenic Differentiation in Osteoporosis by Down-Regulating KLF 10
by: You M, et al.
Published: (2021-01-01)

Circ_0067934 promotes non-small cell lung cancer development by regulating miR-1182/KLF8 axis and activating Wnt/β-catenin pathway
by: Min Zhao, et al.
Published: (2020-09-01)

Farmacología - ME143 201602
by: Aliaga Viera, Segundo Eleazar, et al.
Published: (2019)

Farmacología - ME143 201700
by: Aliaga Viera, Segundo Eleazar, et al.
Published: (2019)

Farmacología - ME143 201701
by: Aliaga Viera, Segundo Eleazar, et al.
Published: (2019)

KLF7/VPS35 axis contributes to hepatocellular carcinoma progression through CCDC85C-activated β-catenin pathway
by: Yarong Guo, et al.
Published: (2021-04-01)

Gene co-expression network analysis identifies BRCC3 as a key regulator in osteogenic differentiation of osteoblasts through a β-catenin signaling dependent pathway
by: Lixiong Cai, et al.
Published: (2019-02-01)

Animación 2d-DG143-201302
by: Arakaki Ueyonahara Christian David
Published: (2020)

Animación 2d-DG143-201401
by: Arakaki Ueyonahara Christian David
Published: (2020)

Animación 2d-DG143-201402
by: Arakaki Ueyonahara Christian David
Published: (2020)

Animación 2d-DG143-201501
by: Arakaki Ueyonahara Christian David, et al.
Published: (2020)

Animación 2d-DG143-201502
by: Pasco Alfaro Raul Rodrigo, et al.
Published: (2020)

Animación 2d-DG143-201601
by: Pasco Alfaro Raul Rodrigo, et al.
Published: (2020)

Animación 2d-DG143-201602
by: Pasco Alfaro Raul Rodrigo, et al.
Published: (2020)

Animación 2d-DG143-201701
by: Pasco Alfaro Raul Rodrigo, et al.
Published: (2020)

FOXQ1 promotes the osteogenic differentiation of bone mesenchymal stem cells via Wnt/β-catenin signaling by binding with ANXA2
by: Lusai Xiang, et al.
Published: (2020-09-01)

ROLES OF KRÜPPEL LIKE FACTORS KLF1, KLF2, AND KLF4 IN EMBRYONIC BETA-GLOBIN GENE EXPRESSION
by: Alhashem, Yousef
Published: (2009)

The Circular RNA circRNA124534 Promotes Osteogenic Differentiation of Human Dental Pulp Stem Cells Through Modulation of the miR-496/β-Catenin Pathway
by: Fang Ji, et al.
Published: (2020-04-01)

All-trans retinoic acid and COX-2 cross-talk to regulate BMP9-induced osteogenic differentiation via Wnt/β-catenin in mesenchymal stem cells
by: Han Wang, et al.
Published: (2019-10-01)

MFN2 knockdown promotes osteogenic differentiation of iPSC-MSCs through aerobic glycolysis mediated by the Wnt/β-catenin signaling pathway
by: Deng, L., et al.
Published: (2022)

mircroRNA-152 prevents the malignant progression of atherosclerosis via down-regulation of KLF5
by: Wei Wang, et al.
Published: (2019-01-01)

Ganoderal A effectively induces osteogenic differentiation of human amniotic mesenchymal stem cells via cross-talk between Wnt/β-catenin and BMP/SMAD signaling pathways
by: Yi-Qing Wang, et al.
Published: (2020-03-01)

Inhibition of the HEG1–KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells
by: Miguel Alejandro Lopez‐Ramirez, et al.
Published: (2021-05-01)

Bone Marrow Mesenchymal Stem Cells-Derived Extracellular Vesicles Promote Proliferation, Invasion and Migration of Osteosarcoma Cells via the lncRNA MALAT1/miR-143/NRSN2/Wnt/β-Catenin Axis
by: Li F, et al.
Published: (2021-02-01)

SFRP2 enhances the osteogenic differentiation of apical papilla stem cells by antagonizing the canonical WNT pathway
by: Luyuan Jin, et al.
Published: (2017-08-01)

Connexin 43 Modulates Osteogenic Differentiation of Bone Marrow Stromal Cells Through GSK-3beta/Beta-Catenin Signaling Pathways
by: Fei-xiang Lin, et al.
Published: (2018-05-01)

Four and a Half LIM Domains Protein 2 Mediates Bortezomib-Induced Osteogenic Differentiation of Mesenchymal Stem Cells in Multiple Myeloma Through p53 Signaling and β-Catenin Nuclear Enrichment
by: Zhenqing Xie, et al.
Published: (2021-09-01)

Energija budućnosti: Grupa 143 / Energy of the Future: Group 143
by: Maja Stanković
Published: (2014-04-01)

Blue Mussel-Derived Peptides PIISVYWK and FSVVPSPK Trigger Wnt/β-Catenin Signaling-Mediated Osteogenesis in Human Bone Marrow Mesenchymal Stem Cells
by: Yunok Oh, et al.
Published: (2020-10-01)

The Klf6-related super enhancer regulates Klf6-SV2 expression mediated proliferation in human hepatoma (HepG2) cells
by: Kum Chol Ri, et al.
Published: (2019-10-01)

Klf4, Klf2, and Zfp148 activate autophagy‐related genes in smooth muscle cells during aortic aneurysm formation
by: Morgan Salmon, et al.
Published: (2019-04-01)

MicroRNA-143-3p suppresses tumorigenesis by targeting catenin-δ1 in colorectal cancer
by: Ding X, et al.
Published: (2019-05-01)

Upregulation of Parkin Accelerates Osteoblastic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells and Bone Regeneration by Enhancing Autophagy and β-Catenin Signaling
by: Wei Zhang, et al.
Published: (2020-09-01)

MicroRNA-10b regulates epithelial–mesenchymal transition by modulating KLF4/KLF11/Smads in hepatocellular carcinoma
by: Gulibaha Hujie, et al.
Published: (2018-01-01)

Total Flavonoids of Rhizoma Drynariae Promotes Differentiation of Osteoblasts and Growth of Bone Graft in Induced Membrane Partly by Activating Wnt/β-Catenin Signaling Pathway
by: Shuyuan Li, et al.
Published: (2021-05-01)