MiR-143-3p Inhibits Osteogenic Differentiation of Human Periodontal Ligament Cells by Targeting KLF5 and Inactivating the Wnt/β-Catenin Pathway

MiR-143-3p Inhibits Osteogenic Differentiation of Human Periodontal Ligament Cells by Targeting KLF5 and Inactivating the Wnt/β-Catenin Pathway

Human periodontal ligament cells (hPDLCs) play a vital role in cell regeneration and tissue repair with multi-directional differentiation potential. microRNAs (miRs) are implicated in the osteogenesis of hPDLCs. This study explored the mechanism of miR-143-3p in osteogenesis of hPDLCs. Osteogenic di...

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Bibliographic Details
Main Authors: Kaixin Wangzhou, Zhiying Lai, Zishao Lu, Wanren Fu, Cheng Liu, Zhengeng Liang, Yi Tan, Conghui Li, Chunbo Hao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Physiology
Subjects:
human periodontal ligament cells
osteogenic differentiation
microRNA-143-3p
KLF5
Wnt/β-catenin pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.606967/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2020.606967/full

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