Sensitization of ovarian tumor to immune checkpoint blockade by boosting senescence-associated secretory phenotype

Sensitization of ovarian tumor to immune checkpoint blockade by boosting senescence-associated secretory phenotype

Summary: Therapy-induced senescence-associated secretory phenotype (SASP) correlates with overcoming resistance to immune checkpoint blockade (ICB). Intrinsic resistance to ICB is a major clinical challenge. For example, ovarian cancer is largely resistant to ICB. Here we show that adoptive transfer...

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Bibliographic Details
Main Authors: Xue Hao, Bo Zhao, Wei Zhou, Heng Liu, Takeshi Fukumoto, Dmitry Gabrilovich, Rugang Zhang
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:iScience
Subjects:
Molecular Biology
Immunology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422031213X

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