p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression

AMPA receptors mediate excitatory synaptic transmission and are involved in synaptic plasticity. The authors show that p97 interacts with the GluA1 subunit of AMPA receptors, promotes the formation of GluA1 homomeric AMPA receptors, and regulates AMPA receptor trafficking during synaptic plasticity.

Bibliographic Details
Main Authors:	Yuan Ge, Meng Tian, Lidong Liu, Tak Pan Wong, Bo Gong, Dongchuan Wu, Taesup Cho, Shujun Lin, Jürgen Kast, Jie Lu, Yu Tian Wang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-12096-7

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spelling	doaj-91ba58e4597d42e5bf8e2615db1d73f12021-05-11T11:33:27ZengNature Publishing GroupNature Communications2041-17232019-09-0110111610.1038/s41467-019-12096-7p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expressionYuan Ge0Meng Tian1Lidong Liu2Tak Pan Wong3Bo Gong4Dongchuan Wu5Taesup Cho6Shujun Lin7Jürgen Kast8Jie Lu9Yu Tian Wang10Djavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British ColumbiaDjavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British ColumbiaDjavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British ColumbiaDjavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British ColumbiaDjavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British ColumbiaDjavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British ColumbiaDjavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British ColumbiaBiomedical Research Centre, University of British ColumbiaBiomedical Research Centre, University of British ColumbiaDjavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British ColumbiaDjavad Mowafaghian Centre for Brain Health and Department of Medicine, University of British ColumbiaAMPA receptors mediate excitatory synaptic transmission and are involved in synaptic plasticity. The authors show that p97 interacts with the GluA1 subunit of AMPA receptors, promotes the formation of GluA1 homomeric AMPA receptors, and regulates AMPA receptor trafficking during synaptic plasticity.https://doi.org/10.1038/s41467-019-12096-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yuan Ge Meng Tian Lidong Liu Tak Pan Wong Bo Gong Dongchuan Wu Taesup Cho Shujun Lin Jürgen Kast Jie Lu Yu Tian Wang
spellingShingle	Yuan Ge Meng Tian Lidong Liu Tak Pan Wong Bo Gong Dongchuan Wu Taesup Cho Shujun Lin Jürgen Kast Jie Lu Yu Tian Wang p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression Nature Communications
author_facet	Yuan Ge Meng Tian Lidong Liu Tak Pan Wong Bo Gong Dongchuan Wu Taesup Cho Shujun Lin Jürgen Kast Jie Lu Yu Tian Wang
author_sort	Yuan Ge
title	p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression
title_short	p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression
title_full	p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression
title_fullStr	p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression
title_full_unstemmed	p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression
title_sort	p97 regulates glua1 homomeric ampa receptor formation and plasma membrane expression
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-09-01
description	AMPA receptors mediate excitatory synaptic transmission and are involved in synaptic plasticity. The authors show that p97 interacts with the GluA1 subunit of AMPA receptors, promotes the formation of GluA1 homomeric AMPA receptors, and regulates AMPA receptor trafficking during synaptic plasticity.
url	https://doi.org/10.1038/s41467-019-12096-7
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p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression

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