Store-Operated Calcium Entry via STIM1 Contributes to MRGPRX2 Induced Mast Cell Functions

Store-Operated Calcium Entry via STIM1 Contributes to MRGPRX2 Induced Mast Cell Functions

Mast cells are inflammatory immune cells that play an essential role in mediating allergic reactions in humans. It is well-known that mast cell activation is critically regulated by intracellular calcium ion (Ca2+) concentrations. MAS-related G-protein coupled receptor-X2 (MRGPRX2) is a G-protein co...

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Bibliographic Details
Main Authors: Christopher J. Occhiuto, Ananth K. Kammala, Canchai Yang, Rithvik Nellutla, Marco Garcia, Gregorio Gomez, Hariharan Subramanian
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
mast cells
pseudo-allergic reactions
stromal interaction molecule 1 (STIM1)
store-operated calcium entry (SOCE)
MAS-related G-protein coupled receptor-X2 (MRGPRX2)
MrgprB2
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03143/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.03143/full

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