Clearing Extracellular Alpha-Synuclein from Cerebrospinal Fluid: A New Therapeutic Strategy in Parkinson’s Disease

Clearing Extracellular Alpha-Synuclein from Cerebrospinal Fluid: A New Therapeutic Strategy in Parkinson’s Disease

This concept article aims to show the rationale of targeting extracellular α-Synuclein (α-Syn) from cerebrospinal fluid (CSF) as a new strategy to remove this protein from the brain in Parkinson’s disease (PD). Misfolding and intracellular aggregation of α-synuclein into Lewy bodies are thought to b...

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Bibliographic Details
Main Authors: Manuel Menéndez-González, Huber S. Padilla-Zambrano, Cristina Tomás-Zapico, Benjamin Fernández García
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Brain Sciences
Subjects:
Parkinson’s disease
alpha-synuclein
cerebrospinal fluid
immunotherapy
“CSF sink” hypothesis
Online Access:http://www.mdpi.com/2076-3425/8/4/52

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