A Functional Variant Rs492554 Associated With Congenital Heart Defects Modulates SESN2 Expression Through POU2F1

A Functional Variant Rs492554 Associated With Congenital Heart Defects Modulates SESN2 Expression Through POU2F1

Hypoxia exposure is responsible for the high incidence of congenital heart defects (CHDs) in high-altitude areas, which is nearly 20 times higher than that in low-altitude areas. However, the genetic factors involved are rarely reported. Sestrin2 (SESN2), a hypoxia stress-inducible gene, protects ca...

Full description

Bibliographic Details
Main Authors: Wenke Yang, Yi Li, Jun Bai, Tao You, Kang Yi, Dingxiong Xie, Xiaowei Zhang, Xiaodong Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
congenital heart defects
SESN2 gene
single nucleotide polymorphisms
rs492554
high-altitude
hypoxia
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.668474/full

Similar Items

Similar Items