Synchrotron X-ray interlaced microbeams suppress paroxysmal oscillations in neuronal networks initiating generalized epilepsy

Synchrotron X-ray interlaced microbeams suppress paroxysmal oscillations in neuronal networks initiating generalized epilepsy

Radiotherapy has shown some efficacy for epilepsies but the insufficient confinement of the radiation dose to the pathological target reduces its indications. Synchrotron-generated X-rays overcome this limitation and allow the delivery of focalized radiation doses to discrete brain volumes via inter...

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Bibliographic Details
Main Authors: Benoît Pouyatos, Raphaël Serduc, Mathilde Chipaux, Tanguy Chabrol, Elke Bräuer-Krisch, Christian Nemoz, Hervé Mathieu, Olivier David, Luc Renaud, Yolanda Prezado, Jean Albert Laissue, François Estève, Stéphane Charpier, Antoine Depaulis
Format: Article
Language:English
Published: Elsevier 2013-03-01
Series:Neurobiology of Disease
Subjects:
Epilepsy
Animal model
Spike-wave discharges
Radiotherapy
Synchrotron X-ray microbeams
Intracellular recordings
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112003683

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http://www.sciencedirect.com/science/article/pii/S0969996112003683

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