Peutz-Jeghers Type Polyp of the Appendix with Review of Literature

Hamartomatous polyps of Peutz-Jeghers type are strongly associated with Peutz-Jeghers polyposis syndrome and are predominantly encountered in the small intestine. Sporadic cases are uncommonly reported. We report a case of a polyp identified incidentally in the appendix of a patient undergoing diagn...

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Main Authors:	Jolanta Jedrzkiewicz, Keith Quencer, Anna P. Matynia, Ellen Morrow, Maria Pletneva, Gonzalo Barraza
Format:	Article
Language:	English
Published:	Hindawi Limited 2019-01-01
Series:	Case Reports in Pathology
Online Access:	http://dx.doi.org/10.1155/2019/7584070

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spelling	doaj-919b935b3dce4277bfdfbfce1d51b52d2020-11-25T00:29:46ZengHindawi LimitedCase Reports in Pathology2090-67812090-679X2019-01-01201910.1155/2019/75840707584070Peutz-Jeghers Type Polyp of the Appendix with Review of LiteratureJolanta Jedrzkiewicz0Keith Quencer1Anna P. Matynia2Ellen Morrow3Maria Pletneva4Gonzalo Barraza5Department of Pathology, University of Utah, 1950 Circle of Hope, Salt Lake City, UT 84112, USADepartment of Radiology, University of Utah, 1950 Circle of Hope, Salt Lake City, UT 84112, USADepartment of Pathology, University of Utah and ARUP Laboratories, 500 Chipeta Way, Salt Lake City, UT 84108, USADepartment of Surgery, University of Utah, 50 N Medical Dr., Salt Lake City, UT 84132, USADepartment of Pathology, University of Utah, 1950 Circle of Hope, Salt Lake City, UT 84112, USAGeorge E. Wahlen Department of Veterans Affairs Medical Center, Department of Pathology, 500 Foothill Dr, Salt Lake City, UT 84148, USAHamartomatous polyps of Peutz-Jeghers type are strongly associated with Peutz-Jeghers polyposis syndrome and are predominantly encountered in the small intestine. Sporadic cases are uncommonly reported. We report a case of a polyp identified incidentally in the appendix of a patient undergoing diagnostic imaging due to a history of hepatitis C infection. Histopathologic evaluation after appendectomy showed a polyp with bands of muscularis mucosae bundles with arborizing architecture and variable amounts of inspissated mucin, morphologically indistinguishable from Peutz-Jeghers type hamartomatous polyp. A family or personal history of abdominal cancers was not reported by the patient, suggesting a sporadic occurrence. Next generation sequencing revealed only two pathogenic low-level STK11 mutations, presumed to be somatic. In conclusion, this is an unusual case of a sporadic Peutz-Jeghers type polyp occurring in the appendix.http://dx.doi.org/10.1155/2019/7584070
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jolanta Jedrzkiewicz Keith Quencer Anna P. Matynia Ellen Morrow Maria Pletneva Gonzalo Barraza
spellingShingle	Jolanta Jedrzkiewicz Keith Quencer Anna P. Matynia Ellen Morrow Maria Pletneva Gonzalo Barraza Peutz-Jeghers Type Polyp of the Appendix with Review of Literature Case Reports in Pathology
author_facet	Jolanta Jedrzkiewicz Keith Quencer Anna P. Matynia Ellen Morrow Maria Pletneva Gonzalo Barraza
author_sort	Jolanta Jedrzkiewicz
title	Peutz-Jeghers Type Polyp of the Appendix with Review of Literature
title_short	Peutz-Jeghers Type Polyp of the Appendix with Review of Literature
title_full	Peutz-Jeghers Type Polyp of the Appendix with Review of Literature
title_fullStr	Peutz-Jeghers Type Polyp of the Appendix with Review of Literature
title_full_unstemmed	Peutz-Jeghers Type Polyp of the Appendix with Review of Literature
title_sort	peutz-jeghers type polyp of the appendix with review of literature
publisher	Hindawi Limited
series	Case Reports in Pathology
issn	2090-6781 2090-679X
publishDate	2019-01-01
description	Hamartomatous polyps of Peutz-Jeghers type are strongly associated with Peutz-Jeghers polyposis syndrome and are predominantly encountered in the small intestine. Sporadic cases are uncommonly reported. We report a case of a polyp identified incidentally in the appendix of a patient undergoing diagnostic imaging due to a history of hepatitis C infection. Histopathologic evaluation after appendectomy showed a polyp with bands of muscularis mucosae bundles with arborizing architecture and variable amounts of inspissated mucin, morphologically indistinguishable from Peutz-Jeghers type hamartomatous polyp. A family or personal history of abdominal cancers was not reported by the patient, suggesting a sporadic occurrence. Next generation sequencing revealed only two pathogenic low-level STK11 mutations, presumed to be somatic. In conclusion, this is an unusual case of a sporadic Peutz-Jeghers type polyp occurring in the appendix.
url	http://dx.doi.org/10.1155/2019/7584070
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Peutz-Jeghers Type Polyp of the Appendix with Review of Literature

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