Stimulation of glucose uptake in murine soleus muscle and adipocytes by 5-(4-phenoxybutoxy)psoralen (PAP-1) may be mediated by Kv1.5 rather than Kv1.3

Stimulation of glucose uptake in murine soleus muscle and adipocytes by 5-(4-phenoxybutoxy)psoralen (PAP-1) may be mediated by Kv1.5 rather than Kv1.3

Kv1 channels are shaker-related potassium channels that influence insulin sensitivity. Kv1.3−/− mice are protected from diet-induced insulin resistance and some studies suggest that Kv1.3 inhibitors provide similar protection. However, it is unclear whether blockade of Kv1.3 in adipocytes or skeleta...

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Bibliographic Details
Main Authors: Robert A. Ngala, Mohamed S. Zaibi, Kenneth Langlands, Claire J. Stocker, Jonathan R.S. Arch, Michael A. Cawthorne
Format: Article
Language:English
Published: PeerJ Inc. 2014-10-01
Series:PeerJ
Subjects:
Potassium channel
PAP-1
Glucose uptake
Adipocyte
Soleus muscle
TNFα
Online Access:https://peerj.com/articles/614.pdf

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