Silibinin Induces G2/M Cell Cycle Arrest by Activating Drp1-Dependent Mitochondrial Fission in Cervical Cancer

Silibinin Induces G2/M Cell Cycle Arrest by Activating Drp1-Dependent Mitochondrial Fission in Cervical Cancer

Cervical cancer is the fourth leading cancer type and the second most common gynecological malignancy among women worldwide. Silibinin (SB), a chief bioactive natural polyphenolic flavonoid of Silybum marianum L., has been used clinically for its hepatocyte protective effects. It also has anticancer...

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Bibliographic Details
Main Authors: Yanting You, Qiuxing He, Hanqi Lu, Xinghong Zhou, Liqian Chen, Huaxi Liu, Zibin Lu, Dongyi Liu, Yanyan Liu, Daming Zuo, Xiuqiong Fu, Hiuyee Kwan, Xiaoshan Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
silibinin
cervical cancer
G2/M cell cycle arrest
mitochondria fission
dynamin-related protein 1
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00271/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.00271/full

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