Aerobic Glycolysis Is Essential for Normal Rod Function and Controls Secondary Cone Death in Retinitis Pigmentosa

Aerobic Glycolysis Is Essential for Normal Rod Function and Controls Secondary Cone Death in Retinitis Pigmentosa

Aerobic glycolysis accounts for ∼80%–90% of glucose used by adult photoreceptors (PRs); yet, the importance of aerobic glycolysis for PR function or survival remains unclear. Here, we further established the role of aerobic glycolysis in murine rod and cone PRs. We show that loss of hexokinase-2 (HK...

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Bibliographic Details
Main Authors: Lolita Petit, Shan Ma, Joris Cipi, Shun-Yun Cheng, Marina Zieger, Nissim Hay, Claudio Punzo
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Cell Reports
Subjects:
hexokinase-2
aerobic glycolysis
oxidative phosphorylation
rods
cones
rod metabolism
metabolic coupling
retinitis pigmentosa
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718307113

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http://www.sciencedirect.com/science/article/pii/S2211124718307113

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