Surface-Enhanced Raman Spectroscopy (SERS) Tracking of Chelerythrine, a Na+/K+ Pump Inhibitor, into Cytosol and Plasma Membrane Fractions of Human Lens Epithelial Cell Cultures

Surface-Enhanced Raman Spectroscopy (SERS) Tracking of Chelerythrine, a Na+/K+ Pump Inhibitor, into Cytosol and Plasma Membrane Fractions of Human Lens Epithelial Cell Cultures

Background/Aims: The quaternary benzo-phenanthridine alkaloid (QBA) chelerythrine (CET) is a pro-apoptotic drug and Na+/K+ pump (NKP) inhibitor in human lens epithelial cells (HLECs). In order to obtain further insight into the mechanism of NKP inhibition by CET, its sub-cellular distribution was qu...

Full description

Bibliographic Details
Main Authors: Kevin M. Dorney, Ioana E.P. Sizemore, Tariq Alqahtani, Norma C. Adragna, Peter K. Lauf
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-12-01
Series:Cellular Physiology and Biochemistry
Subjects:
Chelerythrine
Human Lens Epithelia
Surface-Enhanced Raman Spectroscopy
Cellular Distribution
Na+/K+ Pump
Online Access:http://www.karger.com/Article/FullText/356634

Internet

http://www.karger.com/Article/FullText/356634

Similar Items