Molecular Pathogenesis of Neuromyelitis Optica

Molecular Pathogenesis of Neuromyelitis Optica

Neuromyelitis optica (NMO) is a rare autoimmune disorder, distinct from multiple sclerosis, causing inflammatory lesions in the optic nerves and spinal cord. An autoantibody (NMO IgG) against aquaporin-4 (AQP4), a water channel expressed on astrocytes is thought to be causative. Peripheral productio...

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Bibliographic Details
Main Authors: Simon A Broadley, Kerri Prain, Michael H Barnett, Wajih Bukhari
Format: Article
Language:English
Published: MDPI AG 2012-10-01
Series:International Journal of Molecular Sciences
Subjects:
pathogenesis
Devic’s disease
immunology
genetics
neuromyelitis optica
multiple sclerosis
aquaporin-4
astrocytopathy
astrocyte
Online Access:http://www.mdpi.com/1422-0067/13/10/12970

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