Proliferative senescence in hematopoietic stem cells during ex-vivo expansion.
The good outcome of hematopoietic stem cell (HSC) transplantation is hampered by low doses of CD34+ cell infusion. Transplanted HSCs undergo a replicative stress that causes accelerated senescence due to rapid telomere shortening. The expansion of human cord blood HSCs is instrumental in obtaining a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Via Medica
2005-12-01
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| Series: | Folia Histochemica et Cytobiologica |
| Online Access: | http://czasopisma.viamedica.pl/fhc/article/view/4596 |