Sildenafil delays the intestinal transit of a liquid meal in awake rats

Sildenafil delays the intestinal transit of a liquid meal in awake rats

Sildenafil slows down the gastric emptying of a liquid test meal in awake rats and inhibits the contractility of intestinal tissue strips. We studied the acute effects of sildenafil on in vivo intestinal transit in rats. Fasted, male albino rats (180-220 g, N = 44) were treated (0.2 mL, iv) with sil...

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Bibliographic Details
Main Authors: J.R.V Graça, G.M Macedo, R.C Palheta Jr, F. de A.A Gondim, R.O Nogueira, J.M Correia, F.H Rola, R.B Oliveira, M.A.N Souza, A.A Santos
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2008-01-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Intestinal transit
Mean arterial pressure
Scintigraphy
Sildenafil
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000100012

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