The impact of microRNAs on transcriptional heterogeneity and gene co-expression across single embryonic stem cells

The impact of microRNAs on transcriptional heterogeneity and gene co-expression across single embryonic stem cells

MicroRNAs can posttranscriptionally repress multiple targets in a cell population. Here the authors use single-cell sequencing to investigate the effects of an individual miRNA on transcriptional heterogeneity and gene co-expression

Bibliographic Details
Main Authors: Gennaro Gambardella, Annamaria Carissimo, Amy Chen, Luisa Cutillo, Tomasz J. Nowakowski, Diego di Bernardo, Robert Blelloch
Format: Article
Language:English
Published: Nature Publishing Group 2017-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14126
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spelling doaj-915b924b7b1a49c5860ec77d7652288d2021-05-11T07:01:52ZengNature Publishing GroupNature Communications2041-17232017-01-018111110.1038/ncomms14126The impact of microRNAs on transcriptional heterogeneity and gene co-expression across single embryonic stem cellsGennaro Gambardella0Annamaria Carissimo1Amy Chen2Luisa Cutillo3Tomasz J. Nowakowski4Diego di Bernardo5Robert Blelloch6Telethon Institute of Genetics and MedicineTelethon Institute of Genetics and MedicineThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences, University of CaliforniaTelethon Institute of Genetics and MedicineThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences, University of CaliforniaTelethon Institute of Genetics and MedicineThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences, University of CaliforniaMicroRNAs can posttranscriptionally repress multiple targets in a cell population. Here the authors use single-cell sequencing to investigate the effects of an individual miRNA on transcriptional heterogeneity and gene co-expressionhttps://doi.org/10.1038/ncomms14126
collection DOAJ
language English
format Article
sources DOAJ
author Gennaro Gambardella
Annamaria Carissimo
Amy Chen
Luisa Cutillo
Tomasz J. Nowakowski
Diego di Bernardo
Robert Blelloch
spellingShingle Gennaro Gambardella
Annamaria Carissimo
Amy Chen
Luisa Cutillo
Tomasz J. Nowakowski
Diego di Bernardo
Robert Blelloch
The impact of microRNAs on transcriptional heterogeneity and gene co-expression across single embryonic stem cells
Nature Communications
author_facet Gennaro Gambardella
Annamaria Carissimo
Amy Chen
Luisa Cutillo
Tomasz J. Nowakowski
Diego di Bernardo
Robert Blelloch
author_sort Gennaro Gambardella
title The impact of microRNAs on transcriptional heterogeneity and gene co-expression across single embryonic stem cells
title_short The impact of microRNAs on transcriptional heterogeneity and gene co-expression across single embryonic stem cells
title_full The impact of microRNAs on transcriptional heterogeneity and gene co-expression across single embryonic stem cells
title_fullStr The impact of microRNAs on transcriptional heterogeneity and gene co-expression across single embryonic stem cells
title_full_unstemmed The impact of microRNAs on transcriptional heterogeneity and gene co-expression across single embryonic stem cells
title_sort impact of micrornas on transcriptional heterogeneity and gene co-expression across single embryonic stem cells
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-01-01
description MicroRNAs can posttranscriptionally repress multiple targets in a cell population. Here the authors use single-cell sequencing to investigate the effects of an individual miRNA on transcriptional heterogeneity and gene co-expression
url https://doi.org/10.1038/ncomms14126
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