A Positive Regulatory Loop between a Wnt-Regulated Non-coding RNA and ASCL2 Controls Intestinal Stem Cell Fate

A Positive Regulatory Loop between a Wnt-Regulated Non-coding RNA and ASCL2 Controls Intestinal Stem Cell Fate

The canonical Wnt pathway plays a central role in stem cell maintenance, differentiation, and proliferation in the intestinal epithelium. Constitutive, aberrant activity of the TCF4/β-catenin transcriptional complex is the primary transforming factor in colorectal cancer. We identify a nuclear long...

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Bibliographic Details
Main Authors: Antonis Giakountis, Panagiotis Moulos, Vasiliki Zarkou, Christina Oikonomou, Vaggelis Harokopos, Artemis G. Hatzigeorgiou, Martin Reczko, Pantelis Hatzis
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716306210

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