Therapeutic role of taurine as antioxidant in reducing hypertension risks in rats

• Main Authors: Marwan A. Ibrahim, Mostafa M. Eraqi, Faiz A. Alfaiz
• Format: Article
• Language: English
• Published: Elsevier 2020-01-01
• Series: Heliyon
• Subjects: Biochemistry; Regenerative medicine; Public health; Pharmacology; Hypertensive rats; Taurine
• Online Access: http://www.sciencedirect.com/science/article/pii/S2405844020300542

Aim: The current investigation focused on the therapeutic role of the administration of taurine on hypertensive rats to reduce or cure the hazard effects of hypertension problems. Methodology: This research included 2 experiments; 1st was done to survey the variations that might occur in blood pressure (BP) of male rats because of the fed 8% NaCl diet for 4 weeks. 2nd experiment, it contains normal control rats', hypertensive rats were served as hypertension recovery group and hypertensive rats were took orally by the help of gastric tube 50 mg taurine/100 g b.wt/day for four weeks and served as taurine group. Results: 1st experimental, clarified a significant elevation in BP, body weight, serum cholesterol, triglycerides, LDL, activities of serum cardiac enzymes, endothelin-1, ADMA, MDA and TNF-α in hypertensive rats' group. On contrary, there is a significant reduction in serum level of TNO and antioxidant enzymes level in relation to the control group. A numerical variation but not statistically significant was happened in HDL in hypertensive rats' group as compared to their matching results in control rats' group. 2nd experimental taurine significantly reduced the BP as compared with hypertensive control. Furthermore, a significant improvement occurred in the mean value of most investigation parameters in hypertensive animal group which treated with taurine. Conclusion: The previous data could be concluded that, there is an obvious amelioration effects of taurine on hypertensive rats by reducing the hazard effects of hypertension problems. The primary mechanisms were discussed according to existing published investigations.