P6.9 MEASURING ARTERIAL STIFFNESS USING POPMETRE® IN THE AFRICAN HETEROZYGOUS AND HOMOZYGOUS SICKLE CELL DISEASE

• Main Authors: Valentine Ouédraogo, Hasan Obeid*, Magid Hallab, Isabelle Signolet, Mor Diaw, Amadou Ba, Georges Lefthériotis
• Format: Article
• Language: English
• Published: Atlantis Press 2015-11-01
• Series: Artery Research
• Online Access: https://www.atlantis-press.com/article/125930656/view

Aim: The sickle cell trait (SCT) is the heterozygous and benign form of the homozygous SC disease (SCD). Although SCT exhibits hemorheological disturbances and increased oxidative stress, its exact role in the development of cardiovascular disease in SCT remains to be determined. The present study sought to determine the arterial stiffness, an independent marker of sub-clinical atherosclerosis, between SCT and trained SCD. Materials and methods: Twelve SCT (43±11yrs, 6 males) were compared to 14 trained younger SCD (29±9yrs, 2 males) and 26 controls with normal hemoglobin (36±11rs, 13 males). Aortic (AoStiff-Physioflow) and peripheral arterial stiffness (pOpmetre-Axelife-France) assessed by foot-to-toe pulse wave velocity (ft-PWV), blood pressure (BP) and Framingham-Laurier cardiovascular risk score (CVR in %) were measured in each group. Results: SCT exhibited stiffer arteries (Aostiff: 5.8±0.71 m/s, ft-PWV: 10.9±6.2 m/s) than controls (Aostiff = 4.8±0.5 m/s, ft-PWV: 7.7±2.6 m/s) and SCD (Aostiff = 4.9±0.6 m/s, p=0.001, ft-PWV: 6.1±0.9 m/s p=0.003). SCT were older (p=0.001) than controls and SCD. The systolic and mean AP were lower in SCD than controls and SCT. In the whole group, the CVR score was the major contributor to PerStiff (r2=0.402, p<0.0001) while AoStiff was mainly associated to the hemoglobin abnormalities (r2=0.291, p<0.0001). Conclusion: Both central and peripheral arterial stiffness are increased in SCT compared to SCD. Our data suggest that hemoglobin abnormalities and CVR play a differential role in the observed changes.