Prevalence of Human Papillomavirus in Women from Mexico City
Introduction. Cervical cancer is the most common cancer among Mexican women. The goal of the present study was to determine the prevalence and distribution of HPV types in women from Mexico City. Methods. Our study was conducted in the Clinica de Especialidades de la Mujer de la Secretaría de la Def...
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Series: | Infectious Diseases in Obstetrics and Gynecology |
Online Access: | http://dx.doi.org/10.1155/2012/384758 |
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doaj-91443a1c6edc485fb63ad09897c98be72020-11-24T23:46:53ZengHindawi LimitedInfectious Diseases in Obstetrics and Gynecology1064-74491098-09972012-01-01201210.1155/2012/384758384758Prevalence of Human Papillomavirus in Women from Mexico CityMaría Guadalupe López Rivera0Maria Olivia Medel Flores1José D’Artagnan Villalba Magdaleno2Virginia Sánchez Monroy3Laboratorio Multidisciplinario de Investigación, Escuela Militar de Graduados de Sanidad, Universidad del Ejército y Fuerza Aérea, 11620 México, DF, MexicoLaboratorio de Biomedicina Molecular I, Programa Institucional de Biomedicina Molecular, Escuela Nacional de Medicina y Homeopatía, IPN, 07320 México, DF, MexicoUniversidad del Valle de México, Campus Chapultepec, Avenida Constituyentes 151, Col. San Miguel Chapultepec, 11850 México, DF, MexicoLaboratorio Multidisciplinario de Investigación, Escuela Militar de Graduados de Sanidad, Universidad del Ejército y Fuerza Aérea, 11620 México, DF, MexicoIntroduction. Cervical cancer is the most common cancer among Mexican women. The goal of the present study was to determine the prevalence and distribution of HPV types in women from Mexico City. Methods. Our study was conducted in the Clinica de Especialidades de la Mujer de la Secretaría de la Defensa Nacional, Mexico. Random samples were taken from 929 healthy women requesting a cervical Papanicolaou examination. Detection and genotyping of HPV were performed by multiplex PCR, with the HPV4A ACE Screening kit (Seegene). Results. 85 of nine hundred twenty-nine women (9.1%) were infected with HPV. Of HPV-positive women, 99% and 1% had high- and low-risk HPV genotypes, respectively. The prevalence of the 16 high-risk (HR) HPV types that were screened was 43% : 42% (18) were HPV positive and 14% (16) were HPV positive, which includes coinfection. Multiple infections with different viral genotypes were detected in 10% of the positive cases. Abnormal cervical cytological results were found in only 15.3% of HPV-positive women, while 84.7% had normal cytological results. Conclusions. We found a similar prevalence of HPV to previous studies in Mexico. The heterogeneity of the HPV genotype distribution in Mexico is evident in this study, which found a high frequency of HPV HR genotypes, the majority of which were HPV 18.http://dx.doi.org/10.1155/2012/384758 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
María Guadalupe López Rivera Maria Olivia Medel Flores José D’Artagnan Villalba Magdaleno Virginia Sánchez Monroy |
spellingShingle |
María Guadalupe López Rivera Maria Olivia Medel Flores José D’Artagnan Villalba Magdaleno Virginia Sánchez Monroy Prevalence of Human Papillomavirus in Women from Mexico City Infectious Diseases in Obstetrics and Gynecology |
author_facet |
María Guadalupe López Rivera Maria Olivia Medel Flores José D’Artagnan Villalba Magdaleno Virginia Sánchez Monroy |
author_sort |
María Guadalupe López Rivera |
title |
Prevalence of Human Papillomavirus in Women from Mexico City |
title_short |
Prevalence of Human Papillomavirus in Women from Mexico City |
title_full |
Prevalence of Human Papillomavirus in Women from Mexico City |
title_fullStr |
Prevalence of Human Papillomavirus in Women from Mexico City |
title_full_unstemmed |
Prevalence of Human Papillomavirus in Women from Mexico City |
title_sort |
prevalence of human papillomavirus in women from mexico city |
publisher |
Hindawi Limited |
series |
Infectious Diseases in Obstetrics and Gynecology |
issn |
1064-7449 1098-0997 |
publishDate |
2012-01-01 |
description |
Introduction. Cervical cancer is the most common cancer among Mexican women. The goal of the present study was to determine the prevalence and distribution of HPV types in women from Mexico City. Methods. Our study was conducted in the Clinica de Especialidades de la Mujer de la Secretaría de la Defensa Nacional, Mexico. Random samples were taken from 929 healthy women requesting a cervical Papanicolaou examination. Detection and genotyping of HPV were performed by multiplex PCR, with the HPV4A ACE Screening kit (Seegene). Results. 85 of nine hundred twenty-nine women (9.1%) were infected with HPV. Of HPV-positive women, 99% and 1% had high- and low-risk HPV genotypes, respectively. The prevalence of the 16 high-risk (HR) HPV types that were screened was 43% : 42% (18) were HPV positive and 14% (16) were HPV positive, which includes coinfection. Multiple infections with different viral genotypes were detected in 10% of the positive cases. Abnormal cervical cytological results were found in only 15.3% of HPV-positive women, while 84.7% had normal cytological results. Conclusions. We found a similar prevalence of HPV to previous studies in Mexico. The heterogeneity of the HPV genotype distribution in Mexico is evident in this study, which found a high frequency of HPV HR genotypes, the majority of which were HPV 18. |
url |
http://dx.doi.org/10.1155/2012/384758 |
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