Prevalence of Human Papillomavirus in Women from Mexico City

Introduction. Cervical cancer is the most common cancer among Mexican women. The goal of the present study was to determine the prevalence and distribution of HPV types in women from Mexico City. Methods. Our study was conducted in the Clinica de Especialidades de la Mujer de la Secretaría de la Def...

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Main Authors: María Guadalupe López Rivera, Maria Olivia Medel Flores, José D’Artagnan Villalba Magdaleno, Virginia Sánchez Monroy
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Infectious Diseases in Obstetrics and Gynecology
Online Access:http://dx.doi.org/10.1155/2012/384758
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spelling doaj-91443a1c6edc485fb63ad09897c98be72020-11-24T23:46:53ZengHindawi LimitedInfectious Diseases in Obstetrics and Gynecology1064-74491098-09972012-01-01201210.1155/2012/384758384758Prevalence of Human Papillomavirus in Women from Mexico CityMaría Guadalupe López Rivera0Maria Olivia Medel Flores1José D’Artagnan Villalba Magdaleno2Virginia Sánchez Monroy3Laboratorio Multidisciplinario de Investigación, Escuela Militar de Graduados de Sanidad, Universidad del Ejército y Fuerza Aérea, 11620 México, DF, MexicoLaboratorio de Biomedicina Molecular I, Programa Institucional de Biomedicina Molecular, Escuela Nacional de Medicina y Homeopatía, IPN, 07320 México, DF, MexicoUniversidad del Valle de México, Campus Chapultepec, Avenida Constituyentes 151, Col. San Miguel Chapultepec, 11850 México, DF, MexicoLaboratorio Multidisciplinario de Investigación, Escuela Militar de Graduados de Sanidad, Universidad del Ejército y Fuerza Aérea, 11620 México, DF, MexicoIntroduction. Cervical cancer is the most common cancer among Mexican women. The goal of the present study was to determine the prevalence and distribution of HPV types in women from Mexico City. Methods. Our study was conducted in the Clinica de Especialidades de la Mujer de la Secretaría de la Defensa Nacional, Mexico. Random samples were taken from 929 healthy women requesting a cervical Papanicolaou examination. Detection and genotyping of HPV were performed by multiplex PCR, with the HPV4A ACE Screening kit (Seegene). Results. 85 of nine hundred twenty-nine women (9.1%) were infected with HPV. Of HPV-positive women, 99% and 1% had high- and low-risk HPV genotypes, respectively. The prevalence of the 16 high-risk (HR) HPV types that were screened was 43% : 42% (18) were HPV positive and 14% (16) were HPV positive, which includes coinfection. Multiple infections with different viral genotypes were detected in 10% of the positive cases. Abnormal cervical cytological results were found in only 15.3% of HPV-positive women, while 84.7% had normal cytological results. Conclusions. We found a similar prevalence of HPV to previous studies in Mexico. The heterogeneity of the HPV genotype distribution in Mexico is evident in this study, which found a high frequency of HPV HR genotypes, the majority of which were HPV 18.http://dx.doi.org/10.1155/2012/384758
collection DOAJ
language English
format Article
sources DOAJ
author María Guadalupe López Rivera
Maria Olivia Medel Flores
José D’Artagnan Villalba Magdaleno
Virginia Sánchez Monroy
spellingShingle María Guadalupe López Rivera
Maria Olivia Medel Flores
José D’Artagnan Villalba Magdaleno
Virginia Sánchez Monroy
Prevalence of Human Papillomavirus in Women from Mexico City
Infectious Diseases in Obstetrics and Gynecology
author_facet María Guadalupe López Rivera
Maria Olivia Medel Flores
José D’Artagnan Villalba Magdaleno
Virginia Sánchez Monroy
author_sort María Guadalupe López Rivera
title Prevalence of Human Papillomavirus in Women from Mexico City
title_short Prevalence of Human Papillomavirus in Women from Mexico City
title_full Prevalence of Human Papillomavirus in Women from Mexico City
title_fullStr Prevalence of Human Papillomavirus in Women from Mexico City
title_full_unstemmed Prevalence of Human Papillomavirus in Women from Mexico City
title_sort prevalence of human papillomavirus in women from mexico city
publisher Hindawi Limited
series Infectious Diseases in Obstetrics and Gynecology
issn 1064-7449
1098-0997
publishDate 2012-01-01
description Introduction. Cervical cancer is the most common cancer among Mexican women. The goal of the present study was to determine the prevalence and distribution of HPV types in women from Mexico City. Methods. Our study was conducted in the Clinica de Especialidades de la Mujer de la Secretaría de la Defensa Nacional, Mexico. Random samples were taken from 929 healthy women requesting a cervical Papanicolaou examination. Detection and genotyping of HPV were performed by multiplex PCR, with the HPV4A ACE Screening kit (Seegene). Results. 85 of nine hundred twenty-nine women (9.1%) were infected with HPV. Of HPV-positive women, 99% and 1% had high- and low-risk HPV genotypes, respectively. The prevalence of the 16 high-risk (HR) HPV types that were screened was 43% : 42% (18) were HPV positive and 14% (16) were HPV positive, which includes coinfection. Multiple infections with different viral genotypes were detected in 10% of the positive cases. Abnormal cervical cytological results were found in only 15.3% of HPV-positive women, while 84.7% had normal cytological results. Conclusions. We found a similar prevalence of HPV to previous studies in Mexico. The heterogeneity of the HPV genotype distribution in Mexico is evident in this study, which found a high frequency of HPV HR genotypes, the majority of which were HPV 18.
url http://dx.doi.org/10.1155/2012/384758
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