Downregulation of Runx2 by 1,25-Dihydroxyvitamin D3 Induces the Transdifferentiation of Osteoblasts to Adipocytes

Downregulation of Runx2 by 1,25-Dihydroxyvitamin D3 Induces the Transdifferentiation of Osteoblasts to Adipocytes

1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) indirectly stimulates bone formation, but little is known about its direct effect on bone formation. In this study, we observed that 1,25(OH)2D3 enhances adipocyte differentiation, but inhibits osteoblast differentiation during osteogenesis. The positive role o...

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Bibliographic Details
Main Authors: Jung Ha Kim, Semun Seong, Kabsun Kim, Inyoung Kim, Byung-Chul Jeong, Nacksung Kim
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:International Journal of Molecular Sciences
Subjects:
1,25(OH)2D3
transdifferentiation
osteoblast
adipocyte
Online Access:http://www.mdpi.com/1422-0067/17/5/770

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